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Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review

dc.contributor.authorKushwaha, Prem Prakash
dc.contributor.authorRapalli, Krishna Chaitanya
dc.contributor.authorKumar, Shashank
dc.date.accessioned2018-03-13T10:57:51Z
dc.date.available2018-03-13T10:57:51Z
dc.date.issued2016
dc.identifier.citationKushwaha, P. P., Rapalli, K. C., & Kumar, S. (2016). Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review. Biochimie, 131, 115-127. doi: 10.1016/j.biochi.2016.09.022en_US
dc.identifier.issn3009084
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/655
dc.description.abstractDNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin (GMNN). A conformational change between GMNN-Cdt1 heterotrimer and heterohexamer complex is responsible for licensing or inhibition of the DNA replication. This molecular switch ensures a faithful DNA replication during each S phase of cell cycle. GMNN inhibits Cdt1-mediated minichromosome maintenance helicases (MCM) loading onto the chromatin-bound origin recognition complex (ORC) which results in the inhibition of pre-replication complex assembly. GMNN modulates DNA replication by direct binding to Cdt1, and thereby alters its stability and activity. GMNN is involved in various stages of development such as pre-implantation, germ layer formation, cell commitment and specification, maintenance of genome integrity at mid blastula transition, epithelial to mesenchymal transition during gastrulation, neural development, organogenesis and axis patterning. GMNN interacts with different proteins resulting in enhanced hematopoietic stem cell activity thereby activating the development-associated genes' transcription. GMNN expression is also associated with cancer pathophysiology and development. In this review we discussed the structure and function of GMNN in detail. Inhibitors of GMNN and their role in DNA replication, repair, cell cycle and apoptosis are reviewed. Further, we also discussed the role of GMNN in virus infected host cells. ? 2016 Elsevier B.V. and Soci?t? Fran?aise de Biochimie et Biologie Mol?culaire (SFBBM)en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectGemininen_US
dc.subjectMinichromosome Maintenance Proteinen_US
dc.subjectOrigin Recognition Complexen_US
dc.subjectReplication Licensing Factor Cdt1en_US
dc.subjectGemininen_US
dc.subjectApoptosisen_US
dc.subjectBlastulaen_US
dc.subjectCarcinogenesisen_US
dc.subjectCell Cycle S Phaseen_US
dc.subjectCell Specificityen_US
dc.subjectConformational Transitionen_US
dc.subjectDevelopmental Stageen_US
dc.subjectDna Replicationen_US
dc.subjectEmbryo Pattern Formationen_US
dc.subjectEpithelial Mesenchymal Transitionen_US
dc.subjectGastrulationen_US
dc.subjectGenetic Transcriptionen_US
dc.subjectGenomeen_US
dc.subjectGerm Layeren_US
dc.subjectHematopoietic Stem Cellen_US
dc.subjectHumanen_US
dc.subjectNerve Cell Differentiationen_US
dc.subjectNonhumanen_US
dc.subjectOrganogenesisen_US
dc.subjectPathophysiologyen_US
dc.subjectProtein Assemblyen_US
dc.subjectProteen_US
dc.titleGeminin a multi task protein involved in cancer pathophysiology and developmental process: A reviewen_US
dc.typeReviewen_US
dc.identifier.doi10.1016/j.biochi.2016.09.022
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0300908416302206?via%3Dihub
dc.title.journalBiochimie


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