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High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation

dc.contributor.authorSuman, Prabhat
dc.contributor.authorMishra, Sarthak
dc.contributor.authorChander, Harish
dc.contributor.authorSuman, P.
dc.contributor.authorMishra, S.
dc.contributor.authorChander, H.
dc.date.accessioned2018-06-07T07:31:43Z
dc.date.available2018-06-07T07:31:43Z
dc.date.issued2018
dc.identifier.citationSuman, P., Mishra, S., & Chander, H. (2018). High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. Medical Oncology, 35(5). doi: 10.1007/s12032-018-1132-5en_US
dc.identifier.issn13570560
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/675
dc.description.abstractMetastatic spread of the cancer is usually the consequence of the activation of signaling pathways that generate cell motility and tissue invasion. Metastasis involves the reorganization of cytoskeleton and cell shape for the swift movement of the cells through extracellular matrix. Previously, we have described the invasive and metastatic role played by one of the members (Toca-1) of CIP4 subfamily of F-BAR proteins. In the present study, we address the role of another member (FBP17) of same family in the invasion breast cancer cells. Here, we report that the formin-binding protein 17 (FBP17) is highly expressed at both mRNA and protein levels in breast cancer cells. The study showed the association of FBP17 with cytoskeletal actin regulatory proteins like dynamin and cortactin. To determine its role in extracellular matrix (ECM) degradation, we achieved stable knockdown of FBP17 in MDA-MB-231 cells. FBP17 knockdown cells showed a defect and were found to be compromised in the degradation of ECM indicating the role of FBP17 in the invasion of breast cancer cells. Our results suggest that FBP17 is highly expressed in breast cancer cells and facilitates the invasion of breast cancer cells. ? 2018, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.language.isoen_USen_US
dc.publisherHumana Press Inc.en_US
dc.subjectActinen_US
dc.subjectCortactinen_US
dc.subjectDynaminen_US
dc.subjectFormin Binding Protein 17en_US
dc.subjectMessenger Rnaen_US
dc.subjectProteinen_US
dc.subjectUnclassified Drug Biodegradationen_US
dc.subjectCell Invasionen_US
dc.subjectControlled Studyen_US
dc.subjectExtracellular Matrixen_US
dc.subjectHumanen_US
dc.subjectHuman Cellen_US
dc.subjectMda-Mb-231 Cell Lineen_US
dc.subjectPodosomeen_US
dc.subjectProtein Expressionen_US
dc.subjectProtein Functionen_US
dc.subjectProtein Protein Interactionen_US
dc.titleHigh expression of FBP17 in invasive breast cancer cells promotes invadopodia formationen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12032-018-1132-5
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12032-018-1132-5
dc.title.journalMedical Oncology


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