Browsing School of Health Sciences by Title
Now showing items 155-174 of 397
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Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review
(Elsevier B.V., 2022-10-30)Background: Ferulic acid is a polyphenolic phytoconstituent synthesized from the metabolism of amino acids phenylalanine and tyrosine found in fruits and vegetables. Neurodegenerative disorders have been a thorn in the ... -
Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
(MDPI, 2022-11-08)Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from ... -
Filgrastim, a Recombinant Form of Granulocyte Colony-stimulating Factor, Ameliorates 3-nitropropionic Acid and Haloperidol-induced Striatal Neurotoxicity in Rats
(Springer, 2022-11-17)Striatal neurotoxicity is the pathological hallmark for a heterogeneous group of movement disorders like Tardive dyskinesia (TD) and Huntington�s disease (HD). Both diseases are characterized by progressive impairment in ... -
A focus on Rho/ROCK signaling pathway: An emerging therapeutic target in depression
(Elsevier B.V., 2023-03-08)Depression is the most common mental health disorder worldwide; however, the exact cellular and molecular mechanisms of this major depressive disorder are unclear so far. Experimental studies have demonstrated that depression ... -
Formulation and Evaluation of Ethosomal Gel and Non-ethosomal Gel of S.grandiflora Leaves
(Research Journal of Pharmacy and Technology, 2022-04-13)The numbers of products based on new drug delivery systems have considerably increased in the past few years, and this growth is projected to carry on in the future. These bio-pharmaceuticals present challenges to drug ... -
Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine
(National Taiwan University, 2022-03-22)Background and aim: The ingredients viz., Artemisia roxburghiana, Cissampelos pareira, Stephania glabra, Drimia indica, Roylea cinerea, Tinospora sinensis and Curcuma longa of the present formulation are used to treat ... -
Frequency of pathogenic germline mutations in cancer susceptibility genes in breast cancer patients
(Humana Press Inc., 2018)In this study, we evaluated the incidence of pathogenic germline mutations in 30 breast cancer susceptibility genes in breast cancer patients. Our aim was to understand the involvement of the inherited mutations in these ... -
Fruit waste (peel) as bio-reductant to synthesize silver nanoparticles with antimicrobial, antioxidant and cytotoxic activities
(University of South Bohemia, 2018)Since last decade, biogenic synthesis of metal or metal-oxide nanoparticles is emerging as an alternative method, which is environment friendly, simple and safe to use. In this article, fruit waste (peel) extract (FWE) of ... -
FTIR based approach to study EnaC mechanosensory functions
(Elsevier Ltd, 2021-07-19)The pulmonary epithelial sodium ion channel (ENaC) is gaining importance for its sodium gating and mechanosensitive roles. The mechano functional studies on ENaC suggest direct molecular interactions between the ENaC protein ... -
Functional implications of the CpG island methylation in the pathogenesis of celiac disease
(Springer Science and Business Media B.V., 2022-05-28)Investigation of gene-environment cross talk through epigenetic modifications led to better understanding of the number of complex diseases. Clinical heterogeneity and differential treatment response often contributed by ... -
Galangin, as a Potential Anticancer Agent
(Springer Science and Business Media Deutschland GmbH, 2022-04-07)Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have risen dramatically due to variety of factors. Despite therapeutic alternatives, ... -
GARLIC THE WONDER ADJUVANT IN MEDICINAL FIELD
(2022-05-16)Plant derived compounds are drawing attention in curing and treating variety of ailment and diseases. This increase in popularity of natural products has renewed interest in garlic, which has been used by human for centuries. ... -
Gene therapy: Comprehensive overview and therapeutic applications
(Elsevier Inc., 2022-02-03)Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where the desired gene in the form of plasmids and viral ... -
Gene-editing, immunological and iPSCs based therapeutics for muscular dystrophy
(Elsevier B.V., 2021-10-15)Muscular dystrophy is a well-known genetically heterogeneous group of rare muscle disorders. This progressive disease causes the breakdown of skeletal muscles over time and leads to grave weakness. This breakdown is caused ... -
Generation of Rho-0 Cells using MDA-MB-231 Cell Line and Measurement of Drug Cytotoxicity
(Central University of Punjab, 2018)The ATP generation via Oxidative phosphorylation (OXPHOS) system located in the inner membrane of mitochondria, is regulated by the coordinated interaction between nucleus and mitochondria. In the same context, ... -
Genetic determinants in ischaemic stroke subtypes: Seven year findings and a review
(Elsevier, 2015)Stroke is a global health problem and a leading cause of disability worldwide. There have been numerable studies undertaking research on different aspects of ischaemic stroke employing various epidemiological, clinical and ... -
Genetic signatures in ischemic stroke: Focus on aspirin resistance
(Bentham Science Publishers B.V., 2017)Background and Objective: Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also ... -
Genetic signatures in the treatment of stroke
(Bentham Science Publishers B.V., 2015)Stroke is the fourth leading cause of mortality and neurological disability. It is caused by an intricate interplay of environmental and genetic factors. Genes not only influence susceptibility to stroke but have also been ... -
Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors
(Springer New York LLC, 2017)Phosphodiesterase (PDE) gene family is a large family having at least 21 genes and multiple versions (isoforms) of the phosphodiesterase enzymes. These enzymes catalyze the inactivation of intracellular mediators of signal ... -
Genetic variants of metabolism and inflammatory pathways, and PCOS risk �Systematic review, meta-analysis, and in-silico analysis
(Elsevier B.V., 2023-09-14)Importance: Identification of genetic risk factors for PCOS susceptibility. Objective: To identify genetic risk variants of the genes involved in metabolic or inflammatory pathways. Data sources: Relevant literature was ...