Browsing School of Health Sciences by Title
Now showing items 192-211 of 397
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Health risk assessment of occupationally pesticide-exposed population of cancer prone area of punjab
(Oxford University Press, 2018)The alarming health issues especially the unusually high number of cancer cases in agriculture community of Bathinda district of Punjab (India) is a serious concern. There is limited knowledge about the role of gene-environment ... -
Heterologous expression, purification and characterization of L-type lectin homologue from Leishmania donovani
(Elsevier, 2015)Leishmaniasis, a disease of the developing world affects about 12 million people and has limited therapeutic interventions available. L-type lectins, Endoplasmic Reticulum Golgi Intermediate Compartment/Vesicular Integral ... -
High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation
(Humana Press Inc., 2018)Metastatic spread of the cancer is usually the consequence of the activation of signaling pathways that generate cell motility and tissue invasion. Metastasis involves the reorganization of cytoskeleton and cell shape for ... -
High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues
(Springer Science and Business Media Deutschland GmbH, 2022-08-05)Purpose: The aberrant mRNA expression of a UPR component Cation transport regulator homolog 1 (CHAC1) has been reported to be associated with poor survival in breast and ovarian cancer patients, however, the expression of ... -
High-throughput sequencing technologies in metagenomics
(Elsevier, 2022-09-30)Microbes are a distinct and dynamic group of organisms that require a diverse set of nutritional requirements and environmental conditions to thrive. To culture the desired microorganism a chemically defined media can be ... -
Human-lymphocyte cell friendly starch-hydroxyapatite biodegradable composites: Hydrophilic mechanism, mechanical, and structural impact
(John Wiley and Sons Inc., 2019)Biodegradable starch (Str) polymer was derived from potato, a plant-based natural carbohydrate polymers source, by one-pot synthesis. Hydroxyapatite (HA) was produced from goat bone by step sintering. The inexpensive ... -
Identification of Compounds from Curcuma longa with in Silico Binding Potential against SARS-CoV-2 and Human Host Proteins Involve in Virus Entry and Pathogenesis
(Indian Pharmaceutical Association, 2021-12-07)Severe acute respiratory syndrome coronavirus 2 and associated coronavirus disease 2019 is a newly identified human coronavirus has imposed a serious threat to global health. The rapid transmission of severe acute respiratory ... -
Identification of Novel lncRNA in Breast Cancer Cell Line
(Central University of Punjab, 2018)Long non-coding RNA(lncRNA) is RNA transcript having size of more 200 nucleotides and low number of exons are present due to which it expressed at lower level in specific tissues. Mainly the lncRNA is involved in gene ... -
Identification of novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using Interphase Chromosome Profiling (ICP)
(Blackwell Publishing Ltd, 2018)Conventional cytogenetics has always been a favourite to detect chromosomal aberrations. Carriers of chromosomal translocation are often phenotypically normal but are infertile. Couples are often advised to go for karyotyping, ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020-06-01)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic condition
(Central University of Punjab, 2018)Breast cancer has become the prevailing cause of death, so the research for their treatment has become advanced day by day. Breast cancer behaves differently in normoxic and hypoxic condition so does the anticancer drugs ... -
Imidazole and Derivatives Drugs Synthesis: A Review
(Bentham Science Publishers, 2022-11-22)Imidazoles have long held a special place in heterocyclic chemistry, and their derivatives have piqued interest in recent years due to their diverse chemistry and pharmacology fea-tures. Imidazole is a biologically and ... -
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-? inhibition
(Elsevier Ltd, 2015)Microwave-accelerated synthesis and anticancer activity of novel imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole against a panel of seven cancer cell lines are reported for the ... -
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis
(2013)Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. ... -
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice
(John Wiley and Sons Inc, 2023-09-19)Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, ... -
In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ... -
In Silico Design Of Compounds As Sglt2 Inhibitors
(Central University of Punjab, 2018)SGLT2 inhibitors (SGLT2i) are the current novel therapeutic approach expected to control the growing threat of type 2 diabetes mellitus (T2DM). With comparatively least reported side effects, SGLT2i (gliflozins) have been ... -
In silico disease models of breast cancer
(Springer India, 2014)Breast cancer is a highly heterogeneous disease as a consequence of multiple cells and genetic aberrations. It is the second leading cause of death among women in Western countries. It has been reported that approximately ...