Browsing School of Health Sciences by Title
Now showing items 199-218 of 397
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Identification of Compounds from Curcuma longa with in Silico Binding Potential against SARS-CoV-2 and Human Host Proteins Involve in Virus Entry and Pathogenesis
(Indian Pharmaceutical Association, 2021-12-07)Severe acute respiratory syndrome coronavirus 2 and associated coronavirus disease 2019 is a newly identified human coronavirus has imposed a serious threat to global health. The rapid transmission of severe acute respiratory ... -
Identification of Novel lncRNA in Breast Cancer Cell Line
(Central University of Punjab, 2018)Long non-coding RNA(lncRNA) is RNA transcript having size of more 200 nucleotides and low number of exons are present due to which it expressed at lower level in specific tissues. Mainly the lncRNA is involved in gene ... -
Identification of novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using Interphase Chromosome Profiling (ICP)
(Blackwell Publishing Ltd, 2018)Conventional cytogenetics has always been a favourite to detect chromosomal aberrations. Carriers of chromosomal translocation are often phenotypically normal but are infertile. Couples are often advised to go for karyotyping, ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020-06-01)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Identifying novel miRNA targets of anticancer drugs in normoxic and hypoxic condition
(Central University of Punjab, 2018)Breast cancer has become the prevailing cause of death, so the research for their treatment has become advanced day by day. Breast cancer behaves differently in normoxic and hypoxic condition so does the anticancer drugs ... -
Imidazole and Derivatives Drugs Synthesis: A Review
(Bentham Science Publishers, 2022-11-22)Imidazoles have long held a special place in heterocyclic chemistry, and their derivatives have piqued interest in recent years due to their diverse chemistry and pharmacology fea-tures. Imidazole is a biologically and ... -
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-? inhibition
(Elsevier Ltd, 2015)Microwave-accelerated synthesis and anticancer activity of novel imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole against a panel of seven cancer cell lines are reported for the ... -
Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis
(2013)Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. ... -
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice
(John Wiley and Sons Inc, 2023-09-19)Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, ... -
In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ... -
In Silico Design Of Compounds As Sglt2 Inhibitors
(Central University of Punjab, 2018)SGLT2 inhibitors (SGLT2i) are the current novel therapeutic approach expected to control the growing threat of type 2 diabetes mellitus (T2DM). With comparatively least reported side effects, SGLT2i (gliflozins) have been ... -
In silico disease models of breast cancer
(Springer India, 2014)Breast cancer is a highly heterogeneous disease as a consequence of multiple cells and genetic aberrations. It is the second leading cause of death among women in Western countries. It has been reported that approximately ... -
In silico phytochemical repurposing of natural molecules as entry inhibitors against RBD of the spike protein of SARS-CoV-2 using molecular docking studies
(Inderscience Publishers, 2023-04-18)The receptor binding domain (RBD) of Spike-protein (S-protein) is responsible for virus entry via interaction with host protein ACE2 (angiotensin-converting enzyme 2), present on the cell surface of humans. Therefore, ... -
In silico Studies of Plant-Derived Bioactive Compounds of Wedelia Species
(Bentham Science Publishers, 2022-05-19)Background: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, ... -
In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents
(Bentham Science Publishers, 2023-07-11)Background: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the ... -
Increased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysis
(Taylor and Francis Ltd., 2021-06-25)Background: Spontaneous abortions are the most severe complication of early pregnancy and are a major reproductive health problem. Although this could be caused due to various cytogenetic, immunological, or endocrinological ... -
Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease
(Public Library of Science, 2013)Background:We investigated the pathological and diagnostic role of selected markers of inflammation, oxidant/antioxidant status, and cellular injury in human Chagas disease.Methods:Seropositive/chagasic subjects characterized ... -
Insight into the liver dysfunction in COVID-19 patients: Molecular mechanisms and possible therapeutic strategies
(Baishideng Publishing Group Inc, 2023-04-12)As of June 2022, more than 530 million people worldwide have become ill with coronavirus disease 2019 (COVID-19). Although COVID-19 is most commonly associated with respiratory distress (severe acute respiratory syndrome), ... -
Insights into receptor tyrosine kinases signaling in neurodegenerative disorders: opportunities and translational perspectives
(Elsevier, 2023-07-06)Receptor tyrosine kinases (RTKs) are a group of membrane-bound receptors comprising of extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. RTKs play a crucial role in various ...