Browsing School of Health Sciences by Title
Now showing items 225-244 of 397
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KIBRA Team Up with Partners to Promote Breast Cancer Metastasis
(Springer, 2019)Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized ... -
L-Methionine prevents ?-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
(Elsevier GmbH, 2021-12-03)L-Methionine (L-Met) is an essential sulphur-containing amino acid having a vital role in various key cellular processes. Here we investigated the effect of L-Met on streptozotocin-induced ?-cell damage model of diabetes ... -
L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats
(Royal Society of Chemistry, 2022-03-31)Recently, the protective effects of a methionine-rich diet on hepatic oxidative stress and fibrosis have been suggested but not adequately studied. We, therefore, hypothesized that l-methionine supplementation would ... -
Large-Scale Characterization of the Soil Microbiome in Ancient Tea Plantations Using High-Throughput 16S rRNA and Internal Transcribed Spacer Amplicon Sequencing
(Frontiers Media S.A., 2021-10-16)There is a special interaction between the environment, soil microorganisms, and tea plants, which constitute the ecosystem of tea plantations. Influenced by environmental factors and human management, the changes in soil ... -
Lessons Learned from Cohort Studies, and Hospital-Based Studies and Their Implications in Precision Medicine
(Elsevier Inc., 2017)Advances in human genomics and cutting-edge technologies have created space for integrating personalized or precise medicine into the practice of medicine and thereby improving the public health. Achieving the goal of ... -
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ... -
Literature survey of HDACs in cancer and in-vitro analysis of HDAC inhibitor mediated chemo-sensitization
(Central University of Punjab, 2018)HDACs are chromatin modifying enzymes and post translational modifiers regulating transcription and activity of various proteins such as tubulin, Hsp90 and cortactin respectively. HDAC is divided into four classes (Class ... -
Long non-coding RNAs involved in different steps of cancer metastasis
(Springer Science and Business Media Deutschland GmbH, 2022-02-04)Non-proteincoding transcripts bearing 200 base pairs known as long non-coding RNAs (lncRNAs) play a role in a variety of molecular mechanisms, including cell differentiation, apoptosis and metastasis. Previous studies have ... -
A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity
(2012)Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association ... -
Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives
(MDPI, 2022-11-01)Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous ... -
Management of Chemotherapy Induced Nausea Vomiting (CINV) in Breast Cancer Patients: An Imperative Factor in Patient Compliance
(Elsevier Inc., 2023-05-11)Surgery combined with radiation therapy, with or without systemic chemotherapy, hormone therapy, and antihuman epidermal growth factor receptor 2 targeted therapy, is the standard of care for treating breast cancer. Patients ... -
Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ... -
Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review
(John Wiley and Sons Ltd, 2023-01-30)Background: Recurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples. Objective: To investigate the relationship between variants in the candidate susceptibility ... -
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980�2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1
(Elsevier B.V., 2021-07-21)Background: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020-06-17)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models
(Springer Science and Business Media Deutschland GmbH, 2023-11-03)Background: Melittin is a water-soluble cationic peptide derived from bee venom that has been thoroughly studied for the cure of different cancers. However, the unwanted interactions of melittin produce hemolytic and ... -
Mesenchymal stem cells- an excellent therapeutic agent for cancer
(John Wiley and Sons Inc, 2023-05-16)Despite rapid advancement in research of diagnostics and therapeutics, cancer is the most dangerous disease-causing millions of deaths worldwide. Many of the conventional anticancer therapies can even lead to developing ... -
Meta-analysis and estimation of gene expression to establish the role of SFTPD in COPD
(Central University of Punjab, 2018)COPD is considered to be third leading cause of death by 2020. So far, there is no proper biomarker available for the diagnosis of all the different sub-phenotypes. Multiple GWAS studies have reported the role of SFTPD ...