Browsing School of Health Sciences by Title
Now showing items 321-340 of 397
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Recent advancements in mechanistic studies and structure activity relationship of FoF1 ATP synthase inhibitor as antimicrobial agent
(Elsevier Masson SAS, 2019)The emergence of drug resistance in infectious microbial strains can be overcome by development of novel drug molecules against unexploited microbial target. The success of Bedaquiline in recent years, as FoF1 ATP synthase ... -
Recent advances in HER2 positive breast cancer epigenetics: Susceptibility and therapeutic strategies
(Elsevier Masson SAS, 2017)HER2 amplification/overexpression accounts for aggressive clinical features of HER2 positive breast cancer. Epigenetic changes including DNA methylation, histone modifications and ncRNAs/miRNAs are associated with regulation ... -
Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and technologies
(Editions de Sante, 2023-08-09)Microwave irradiation technology has a lot of applications in the field of food processing, organic synthesis, pharmaceuticals, and biomedical therapy. The basic mechanisms observed in microwave-assisted syntheses are ... -
Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer�s Disease
(Springer, 2021-11-02)Alzheimer�s disease (AD) is a neurodegenerative disorder which leads to mental deterioration due to aberrant accretion of misfolded proteins in the brain. According to mitochondrial cascade hypothesis, mitochondrial ... -
Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer�s disease
(Springer Science and Business Media Deutschland GmbH, 2021-11-23)Alzheimer�s disease (AD) is a major contributor of dementia leading to the degeneration of neurons in the brain with major symptoms like loss of memory and learning. Many evidences suggest the involvement of neuroinflammation ... -
Recent advances in the omics-based assessment of microbial consortia in the plastisphere environment: Deciphering the dynamic role of hidden players
(Institution of Chemical Engineers, 2023-06-10)Continuous disposal of plastic waste and its accretion in the environment is the biggest challenge the world has ever faced. Breaking its terrestrial bounds, plastic waste has now extended its outreach to aquatic territories ... -
Recent updates on the therapeutic potential of HER2 tyrosine kinase inhibitors for the treatment of breast cancer
(Bentham Science Publishers B.V., 2018)HER2 positive breast cancer is characterized by the low survival rate in the metastatic patients. Development of resistance and disease-relapse are the major problems associated with the currently available therapies for ... -
Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
(Elsevier Inc., 2022-08-01)Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered one of the most common causes of dementia worldwide, accounting for about 80 % of all dementia cases. AD is manifested by the extraneuronal ... -
Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment
(2012)Background: GAD65 (Glutamic acid decarboxylase 65 KDa isoform) is one of the most important auto-antigens involved in Type 1 diabetes induction. Although it serves as one of the first injury markers of ?-islets, the ... -
Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
(Springer Science and Business Media Deutschland GmbH, 2022-12-05)Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock for the management of malaria globally. Recent works have implied that they could be used to manage ... -
Research advances in Apert syndrome
(Elsevier B.V., 2018)Apert syndrome is one of the several genetic syndromes associated with craniosynostosis, a condition that includes premature fusion of one or multiple cranial sutures. There has been significant clinical variation among ... -
Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review
(Wolters Kluwer Medknow Publications, 2021-08-18)Since the onset of COVID-19 pandemic, parallel opportunistic infections have also been emerging as another disease spectrum. Among all these opportunistic infection, mucormycosis has become a matter of concern with its ... -
Ring chromosome 22: A review of the literature and first report from India
(2012)Ring chromosome 22 [r(22)], a rare cytogenetic finding, has been described in nearly 70 cases to date. Cytogenetic investigations were carried out on a 5-year-old male child with microcephaly and intellectual disability. ... -
Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2022-12-16)Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains ... -
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
(Bentham Science Publishers B.V., 2017)Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ... -
Role of Hedgehog and Hippo signaling pathways in cancer: A special focus on non-coding RNAs
(Academic Press, 2022-10-28)Despite advanced clinical and translational oncology research, mortality rates are still increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and ... -
Role of lncRNAs in the Development of Ischemic Stroke and Their Therapeutic Potential
(Springer, 2021-04-05)Stroke is a major cause of premature mortality and disability around the world. Therefore, identification of cellular and molecular processes implicated in the pathogenesis and progression of ischemic stroke has become a ... -
Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
(Springer, 2022-01-13)Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus ... -
Role of Omics in Migraine Research and Management: A Narrative Review
(Springer, 2022-07-07)Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors ... -
Role of p53 gene in breast cancer: Focus on mutation spectrum and therapeutic strategies
(Bentham Science Publishers B.V., 2018)TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression of various genes that are directly or indirectly under the ...