Browsing School of Health Sciences by Title
Now showing items 369-388 of 397
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Targeting calcium homeostasis and impaired inter-organelle crosstalk as a potential therapeutic approach in Parkinson's disease
(Elsevier Inc., 2023-08-02)Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremors, rigidity, and ... -
Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
(Elsevier B.V., 2023-06-29)Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal imbalance, increased astrocytes & microglia, ... -
Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
(Springer Nature, 2022-01-31)Mitochondria are important for the metabolism of energy, regulation of apoptosis and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells; moreover, ... -
Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
(Springer Singapore, 2022-09-28)Mitochondria are essential for the metabolism of energy, regulation of apoptosis, and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells. Moreover, ... -
Targeting mitochondria in the regulation of neurodegenerative diseases: A comprehensive review
(John Wiley and Sons Inc, 2022-07-20)Mitochondria are one of the essential cellular organelles. Apart from being considered as the powerhouse of the cell, mitochondria have been widely known to regulate redox reaction, inflammation, cell survival, cell death, ... -
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer: An Indian Perspective
(Springer Singapore, 2022-09-28)Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the importance ... -
TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice
(American Society for Microbiology, 2016)Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, ... -
Temozolomide and flavonoids against glioma: from absorption and metabolism to exosomal delivery
(Springer Science and Business Media Deutschland GmbH, 2023-08-11)Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide increases GBM patient survival, it has also been connected to negative ... -
Therapeutic Strategies Targeting Signaling Pathways in Lung Cancer
(Springer Nature, 2021-07-02)Recent knowledge of the role of signaling pathways and their underlying mechanisms in the pathogenesis of several diseases may lead to the development of therapeutic strategies. In the recent time, several drug molecules ... -
Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development
(Elsevier B.V., 2023-10-21)The formation and progression of tumors in humans are linked to the abnormal development of new blood vessels known as neo-angiogenesis. Angiogenesis is a broad word that encompasses endothelial cell migration, proliferation, ... -
Time to Educate Physicians and Hospital Staff in Electronic Medical Records for Precision Medicine
(Elsevier Inc., 2017)Over the past decade, inexpensive and dense sequencing technologies have led to many genetic discoveries. Single nucleotide polymorphisms associated with over 250 different phenotypes have been identified by genome-wide ... -
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
(BioMed Central Ltd., 2014)Introduction: Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in ... -
Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia
(Bentham Science Publishers, 2023-01-06)Background: Anaemia is the most common disease that affects mostly females and children and is most prevalent in developing countries. Among various causes sickle cell anaemia is one of them, which is a cause of concern. ... -
Trans-cinnamaldehyde mitigates rotenone-induced neurotoxicity via inhibiting oxidative stress in rats
(Elsevier B.V., 2022-12-21)Background: The second most prevalent age-related brain condition, Parkinson's disease (PD) is characterised by the loss of neurons in the substantia nigra pars compacta (SNpc). It is associated with symptoms like bradykinesia, ... -
Transcriptional Regulation of Pro-metastatic Protein Formin Binding Protein17 (FBP17) in Breast Cancer
(Central University of Punjab, 2018)Breast cancer is a diverse disease with multiple subtypes. Among the different molecular subtypes, triple negative breast cancers (TNBC) harbor frequent mutation in tumor suppressor p53. Recently it was shown that p53 ... -
Transferrin decorated PLGA encumbered moxifloxacin nanoparticles and in�vitro cellular studies
(Taylor and Francis Ltd., 2023-03-05)Purpose: Complicated intra-abdominal infection (cIAI) management involves administering antibiotics that destroy the cell wall and the genesis of bacterial lipopolysaccharide (LPS). During the infectious state, the expression ... -
Translation and Validation of ID.Migraine Questionnaire to North-Indian Vernacular Languages
(Wolters Kluwer Medknow Publications, 2023-09-11)Background: ID-Migraine is an established screening tool for migraine. Translation and validation in more languages can increase its reach and scope. Aim: To translate and validate ID-Migraine for screening migraine patients ... -
Translational implications of humoral and cellular immune dysfunction in granulomatosis with polyangiitis
(Academic Press, 2023-02-20)Granulomatosis with polyangiitis (GPA) is a rare systemic ANCA (Anti-neutrophil cytoplasmic antibodies) associated vasculitis (AAV). In the last couple of decades, GPA has emerged as a disease of concern due to rapid ... -
Treatment of diabetic complications: do flavonoids holds the keys?
(Taylor and Francis Ltd., 2023-07-12)Diabetes mellitus (DM) is an endocrinological disorder in which blood sugar levels get elevated and if unmanaged, it leads to several critical complications. Existing therapies or drugs are not able to attain absolute ... -
Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders
(Wiley-Hindawi, 2023-10-12)Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological ...