Browsing School of Health Sciences by Subject "Apoptosis"
Now showing items 1-9 of 9
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Apoptosis in Alzheimer�s disease: insight into the signaling pathways and therapeutic avenues
(Springer, 2023-04-26)Alzheimer�s disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-? (A?) protein resulting in synaptic loss and apoptosis. A? and tau deposition trigger apoptotic pathways that result in ... -
Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement
(Springer Science and Business Media Deutschland GmbH, 2023-04-03)The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. ... -
Bacillus calmette gaurine vaccine ameliorates the neurotoxicity of quinolinic acid in rats via the modulation of antioxidant, inflammatory and apoptotic markers
(Elsevier B.V., 2023-05-11)A mutation in the Huntingtin gene causes �Huntington's disease, which presents as a motor and behavioral impairment. Due to the limited drug therapy for this disease, scientists are constantly searching for newer and ... -
Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review
(Elsevier B.V., 2022-10-30)Background: Ferulic acid is a polyphenolic phytoconstituent synthesized from the metabolism of amino acids phenylalanine and tyrosine found in fruits and vegetables. Neurodegenerative disorders have been a thorn in the ... -
Galangin, as a Potential Anticancer Agent
(Springer Science and Business Media Deutschland GmbH, 2022-04-07)Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have risen dramatically due to variety of factors. Despite therapeutic alternatives, ... -
Mitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disorders
(Elsevier, 2022-03-18)Mitochondria are known to be the powerhouse of the cell. Its dysfunction leads to several alterations in cellular physiology. Mitochondrial dysfunction is a well-documented process in the pathophysiology of neurodegeneration ... -
The mitochondrial unfolded protein response: Role in cellular homeostasis and disease
(Bentham Science Publishers B.V., 2017)Mitochondria are the sole semiautonomous organelles of the human cell and play a very important role in not only energy production but also in apoptosis, metabolism and cell signaling. They are also known to be major ... -
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
(Springer Science and Business Media Deutschland GmbH, 2022-11-28)ROS include hydroxyl radicals (HO.), superoxide (O2.), and hydrogen peroxide (H2O2). ROS are typically produced under physiological conditions and play crucial roles in living organisms. It is known that ROS, which are ... -
Protocols in apoptosis identification and affirmation
(Elsevier, 2020-10-16)Protocols are set of predefined written procedural documents that offer guidance or specifications for performing the experiments and its implementation. They are an essential component of good laboratory practice (GLP) ...