Browsing School of Health Sciences by Subject "Metastasis"
Now showing items 1-10 of 13
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Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome
(Mosby Inc., 2019)Background and Purpose: Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at ... -
Brain metastasis in breast cancer: focus on genes and signaling pathways involved, blood�brain barrier and treatment strategies
(Springer Science and Business Media Deutschland GmbH, 2023-03-10)Breast cancer�(BC) is one of the most prevalent types of cancer in women. Despite advancement in early detection and efficient treatment, recurrence and metastasis continue to pose a significant risk to the life of BC ... -
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis
(Impact Journals, 2015)Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) ... -
Complex roles of discoidin domain receptor tyrosine kinases in cancer
(Springer Science and Business Media Deutschland GmbH, 2021-02-25)Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase (RTK) family that serves as a non-integrin collagen receptor and were initially identified as critical regulators of embryonic development ... -
Differential molecular mechanistic behavior of HDACs in cancer progression
(Springer, 2022-08-16)Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer development. ... -
Expression of KIBRA in Breast Cancer Cell Lines
(Central University of Punjab, 2018)Breast cancer the most frequently diagnosed cancer and its metastasis to distant organs accounts the majority of deaths. Numerous genes and proteins are involved in the cause of metastasis. Though KIBRA is one of the ... -
The genomic architecture of metastasis in breast cancer: focus on mechanistic aspects, signalling pathways and therapeutic strategies
(Springer, 2021-07-16)Breast cancer is a multifactorial, heterogeneous disease and the second most frequent cancer amongst women worldwide. Metastasis is one of the most leading causes of death in these patients. Early-stage or locally advanced ... -
High levels of unfolded protein response component CHAC1 associates with cancer progression signatures in malignant breast cancer tissues
(Springer Science and Business Media Deutschland GmbH, 2022-08-05)Purpose: The aberrant mRNA expression of a UPR component Cation transport regulator homolog 1 (CHAC1) has been reported to be associated with poor survival in breast and ovarian cancer patients, however, the expression of ... -
KIBRA Team Up with Partners to Promote Breast Cancer Metastasis
(Springer, 2019)Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized ... -
Long non-coding RNAs involved in different steps of cancer metastasis
(Springer Science and Business Media Deutschland GmbH, 2022-02-04)Non-proteincoding transcripts bearing 200 base pairs known as long non-coding RNAs (lncRNAs) play a role in a variety of molecular mechanisms, including cell differentiation, apoptosis and metastasis. Previous studies have ...