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Serum Albumin Levels in Breast Cancer: Correlation with Overall Survival
(SciTechnol, 2017)
Introduction: Albumin in an important biomarker that indicates malnutrition as well as inflammation. The aim of the study was to evaluate the albumin levels in breast cancer patients and its association with overall survival ...
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
(Elsevier Masson SAS, 2017)
There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various research groups have reported their role in different types of cancer. The X-ray structures of some CDKs especially CDK2 was exploited in the ...
Apert’s syndrome: study by whole exome sequencing
(Elsevier, 2017)
In the present study we attempted a parent-child trio, whole exome sequencing (WES) approach to study Apert’s syndrome. Clinical characteristics of the child were noted down and WES was carried out using Ion Torrent System ...
Pharmacological and molecular approaches for the treatment of β- hemoglobin disorders
(Wiley, 2017)
β-hemoglobin disorders, such as β-thalassemia and sickle cell anemia are among the most prevalent inherited genetic disorders worldwide. These disorders are caused by mutations in the gene encoding hemoglobin-β (HBB), a ...
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
(Bentham Science Publishers B.V., 2017)
Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ...
CYP/PON genetic variations as determinant of organophosphate pesticides toxicity
(Springer India, 2017)
In the present scenario of increased accumulation of pesticides in the environment, it is important to understand its impact on human health. The focus is on gene?environment interaction, highlighting the consequences and ...
Pesticide Induced Cytotoxicity Analysis in Human Cells
(Krishi Sanskriti Publications, 2017)
The aim of our work was to evaluate the effect of pesticides on cell survival, oxidative stress mechanism in hPBMC (human Peripheral Blood Mononucleated Cells) and lung cancer cells (A549 cell line). Cells were exposed to ...
Assessment of soybean inhibitor as a biopesticide against melon fruit fly, Bactrocera cucurbitae (Coquillett)
(Springer Berlin Heidelberg, 2017)
In the current study, the soybean trypsin?chymotrypsin inhibitor (Bowman?Birk Inhibitor, SBBI) was tested against Bactrocera cucurbitae (Coquillett), a major pest of cucurbit crops. Bioassays conducted using different ...
Alternative pathways for glucose metabolism
(Nova Science Publishers, Inc., 2017)
Glucose metabolism through glycolysis is one of the most fundamental biochemical processes that take place in every living cell. Different enzymes involved in glycolysis are well conserved among different organisms. Pyruvic ...
Chitosan centered bionanocomposites for medical specialty and curative applications: A review
(Elsevier B.V., 2017)
The polyfunctional nature of chitosan enables its application not only in polymer technology but also shows their importance in the field of nanotechnology for the fabrication of the wide spectrum of functional nanomaterials ...