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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy
(Elsevier, 2014)
The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal ...
Characterization of a Kunitz-type serine protease inhibitor from Solanum tuberosum having lectin activity
(Elsevier B.V., 2016)
Plant lectins and protease inhibitors constitute a class of proteins which plays a crucial role in plant defense. In our continuing investigations on lectins from plants, we have isolated, purified and characterized a ...
Breast cancer MicroRNAs: Clinical biomarkers for the diagnosis and treatment strategies
(Springer India, 2014)
Breast cancer is the second most common cancer in females that accounts for the highest cancer-specific deaths worldwide. Although recent advances in clinical management significantly reduced the mortality rate in breast ...
A novel 7 bp deletion in PRPF31 associated with autosomal dominant retinitis pigmentosa with incomplete penetrance in an Indian family
(2012)
To localize and identify the gene linked with non-syndromic autosomal dominant retinitis pigmentosa (adRP) with high but not complete penetrance in an Indian family. A detailed family history and clinical data were recorded. ...
Alternative pathways for glucose metabolism
(Nova Science Publishers, Inc., 2017)
Glucose metabolism through glycolysis is one of the most fundamental biochemical processes that take place in every living cell. Different enzymes involved in glycolysis are well conserved among different organisms. Pyruvic ...
Genetic signatures in ischemic stroke: Focus on aspirin resistance
(Bentham Science Publishers B.V., 2017)
Background and Objective: Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also ...
In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)
Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ...
In silico disease models of breast cancer
(Springer India, 2014)
Breast cancer is a highly heterogeneous disease as a consequence of multiple cells and genetic aberrations. It is the second leading cause of death among women in Western countries. It has been reported that approximately ...
Lessons Learned from Cohort Studies, and Hospital-Based Studies and Their Implications in Precision Medicine
(Elsevier Inc., 2017)
Advances in human genomics and cutting-edge technologies have created space for integrating personalized or precise medicine into the practice of medicine and thereby improving the public health. Achieving the goal of ...
PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor
(2010)
We have examined the association of 14 tagging single nucleotide polymorphisms (tagSNPs) in peroxisome proliferator activated receptor-? transcripts 1 and 2 (PPARG1 and 2) and 5 tagSNPs in adiponectin (ADIPOQ) genes for ...