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Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

Eaves-Pyles, Tonyia; Patel, Jignesh; Arigi, Emma; Cong, Yingzi; Cao, Anthony; Garg, Nisha; Dhiman, Monisha; Pyles, Richard B.; Arulanandam, Bernard; Miller, Aaron L.; Popov, Vsevolod L.; Soong, Lynn; Carlsen, Eric D.; Coletta, Ciro; Szabo, Csaba; Almeida, Igor C.; Eaves-Pyles, T.; Patel, J.; Arigi, E.; Cong, Y.; Cao, A.; Garg, N.; Dhiman, M.; Pyles, R.B.; Arulanandam, B.; Miller, A.L.; Popov, V.L.; Soong, L.; Carlsen, E.D.; Coletta, C.; Szabo, C.; Almeida, I.C. (2013)

Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. ...

Oxidative stress in the development of genetic generalised epilepsy: An observational study in southern Indian population

Prasad, D.K.V.; Satyanarayana, U.; Shaheen, U.; Surya Prabha, T.; Munshi, A. (Journal of Clinical and Diagnostic Research, 2017)

Introduction: Oxidative stress resulting from excessive generation of Reactive Oxygen Species (ROS) plays a significant role in neurodegeneration associated with seizures/epilepsy. Aim: To evaluate oxidative stress markers ...

Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy

Prasad, D.K.V.; Shaheen, U.; Satyanarayana, U.; Prabha, T.S.; Jyothy, A.; Munshi, A. (Elsevier, 2014)

The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal ...

PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor

Sanghera, D.K.; Demirci, F.Y.; Been, L.; Ortega, L.; Ralhan, S.; Wander, G.S.; Mehra, N.K.; Singh, J.; Aston, C.E.; Mulvihill, J.J.; Kamboh, I.M. (2010)

We have examined the association of 14 tagging single nucleotide polymorphisms (tagSNPs) in peroxisome proliferator activated receptor-? transcripts 1 and 2 (PPARG1 and 2) and 5 tagSNPs in adiponectin (ADIPOQ) genes for ...

A novel 7 bp deletion in PRPF31 associated with autosomal dominant retinitis pigmentosa with incomplete penetrance in an Indian family

Saini, S.; Robinson, P.N.; Singh, J.R.; Vanita, V. (2012)

To localize and identify the gene linked with non-syndromic autosomal dominant retinitis pigmentosa (adRP) with high but not complete penetrance in an Indian family. A detailed family history and clinical data were recorded. ...

The mitochondrial unfolded protein response: Role in cellular homeostasis and disease

De, I.; Dogra, N.; Singh, S. (Bentham Science Publishers B.V., 2017)

Mitochondria are the sole semiautonomous organelles of the human cell and play a very important role in not only energy production but also in apoptosis, metabolism and cell signaling. They are also known to be major ...

A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity

Been, L.F.; Hatfield, J.L.; Shankar, A.; Aston, C.E.; Ralhan, S.; Wander, G.S.; Mehra, N.K.; Singh, J.R.; Mulvihill, J.J.; Sanghera, D.K. (2012)

Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association ...

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Imamura, M.; Takahashi, A.; Yamauchi, T.; Hara, K.; Yasuda, K.; Grarup, N.; Zhao, W.; Wang, X.; Huerta-Chagoya, A.; Hu, C.; Moon, S.; Long, J.; Kwak, S.H.; Rasheed, A.; Saxena, R.; Ma, R.C.W.; Okada, Y.; Iwata, M.; Hosoe, J.; Shojima, N.; Iwasaki, M.; Fujita, H.; Suzuki, K.; Danesh, J.; J?rgensen, T.; J?rgensen, M.E.; Witte, D.R.; Brandslund, I.; Christensen, C.; Hansen, T.; Mercader, J.M.; Flannick, J.; Moreno-Mac?as, H.; Burtt, N.P.; Zhang, R.; Kim, Y.J.; Zheng, W.; Singh, J.R.; Tam, C.H.T.; H (Nature Publishing Group, 2016)

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis ...

Association of serum homocysteine and hs-CRP with idiopathic generalised epilepsy and duration of antiepileptic drug therapy

Prasad, D.K.V.; Satyanarayana, U.; Prabhakararao, T.S.; Surya Prabha, T.; Munshi, A. (Journal of Clinical and Diagnostic Research, 2018)

Introduction: Several human and experimental studies have revealed that chronic inflammation may play a vital role in neurodegenerative processes including epilepsy. There is accumulating evidence that inflammatory processes ...

Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease

Dhiman, Monisha; Coronado, Yun A.; Vallejo, Cecillia K.; Peterson, John R.; Ejilemele, Adetoun; Nunez, Sonia; Zago, Maria Paola; Spratt, Hiedi; Garg, Nisha Jain; Dhiman, M.; Coronado, Y.A.; Vallejo, C.K.; Petersen, J.R.; Ejilemele, A.; Nu?ez, S.; Zago, M.P.; Spratt, H.; Garg, N.J. (Public Library of Science, 2013)

Background:We investigated the pathological and diagnostic role of selected markers of inflammation, oxidant/antioxidant status, and cellular injury in human Chagas disease.Methods:Seropositive/chagasic subjects characterized ...