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Serum Albumin Levels in Breast Cancer: Correlation with Overall Survival
(SciTechnol, 2017)
Introduction: Albumin in an important biomarker that indicates malnutrition as well as inflammation. The aim of the study was to evaluate the albumin levels in breast cancer patients and its association with overall survival ...
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors
(Elsevier Masson SAS, 2017)
There are around 20 Cyclin-dependent kinases (CDKs) known till date, and various research groups have reported their role in different types of cancer. The X-ray structures of some CDKs especially CDK2 was exploited in the ...
Apert’s syndrome: study by whole exome sequencing
(Elsevier, 2017)
In the present study we attempted a parent-child trio, whole exome sequencing (WES) approach to study Apert’s syndrome. Clinical characteristics of the child were noted down and WES was carried out using Ion Torrent System ...
Pharmacological and molecular approaches for the treatment of β- hemoglobin disorders
(Wiley, 2017)
β-hemoglobin disorders, such as β-thalassemia and sickle cell anemia are among the most prevalent inherited genetic disorders worldwide. These disorders are caused by mutations in the gene encoding hemoglobin-β (HBB), a ...
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
(Bentham Science Publishers B.V., 2017)
Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ...
Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors
(Springer New York LLC, 2017)
Phosphodiesterase (PDE) gene family is a large family having at least 21 genes and multiple versions (isoforms) of the phosphodiesterase enzymes. These enzymes catalyze the inactivation of intracellular mediators of signal ...
Genetic signatures in ischemic stroke: Focus on aspirin resistance
(Bentham Science Publishers B.V., 2017)
Background and Objective: Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also ...
Lessons Learned from Cohort Studies, and Hospital-Based Studies and Their Implications in Precision Medicine
(Elsevier Inc., 2017)
Advances in human genomics and cutting-edge technologies have created space for integrating personalized or precise medicine into the practice of medicine and thereby improving the public health. Achieving the goal of ...
Recent advances in HER2 positive breast cancer epigenetics: Susceptibility and therapeutic strategies
(Elsevier Masson SAS, 2017)
HER2 amplification/overexpression accounts for aggressive clinical features of HER2 positive breast cancer. Epigenetic changes including DNA methylation, histone modifications and ncRNAs/miRNAs are associated with regulation ...
Role of TLR4 (C1196T) and CD14 (C-260T) Polymorphisms in Development of Ischemic Stroke, Its Subtypes and Hemorrhagic Stroke
(Springer New York LLC, 2017)
In the present study, we evaluated the association of TLR4 and CD14 polymorphisms, i.e. C1196T and C-260T, respectively, with ischemic stroke (n?=?700), its subtypes and hemorrhagic stroke (n?=?300) in a South Indian ...