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In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)
Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ...
Role of p53 gene in breast cancer: Focus on mutation spectrum and therapeutic strategies
(Bentham Science Publishers B.V., 2018)
TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression of various genes that are directly or indirectly under the ...
Synthetic versus enzymatic pictet-spengler reaction: An overview
(Bentham Science Publishers B.V., 2018)
Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having ...
Transcriptional Regulation of Pro-metastatic Protein Formin Binding Protein17 (FBP17) in Breast Cancer
(Central University of Punjab, 2018)
Breast cancer is a diverse disease with multiple subtypes. Among the different molecular subtypes, triple negative breast cancers (TNBC) harbor frequent mutation in tumor suppressor p53. Recently it was shown that p53 ...
Evaluation of the antioxidant, antibacterial and anticancer (lung cancer cell line A549) activity of: Punica granatum mediated silver nanoparticles
(Royal Society of Chemistry, 2018)
This work aimed to synthesize silver nanoparticles via an environmentally benign route, using the aqueous extract of Punica granatum as a precursor as well as a stabilizing and reducing agent. The as-synthesized silver ...
Health risk assessment of occupationally pesticide-exposed population of cancer prone area of punjab
(Oxford University Press, 2018)
The alarming health issues especially the unusually high number of cancer cases in agriculture community of Bathinda district of Punjab (India) is a serious concern. There is limited knowledge about the role of gene-environment ...
Synthetic versus Enzymatic Pictet-Spengler Reaction: An Overview.
(Bentham, 2018)
Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having immense biological ...