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Now showing items 11-20 of 29
Oxidative stress and inflammation in diabetic complications
(Hindawi Publishing Corporation, 2014)
Synthetic versus enzymatic pictet-spengler reaction: An overview
(Bentham Science Publishers B.V., 2018)
Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having ...
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-? inhibition
(Elsevier Ltd, 2015)
Microwave-accelerated synthesis and anticancer activity of novel imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole against a panel of seven cancer cell lines are reported for the ...
Dietary Patterns and Breast Cancer Risk: A Multi-Centre Case Control Study among North Indian Women
(mdpi, 2018)
Evidence from India, a country with unique and distinct food intake patterns often characterized by lifelong adherence, may offer important insight into the role of diet in breast cancer etiology. We evaluated the association ...
Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(Springer, 2018)
Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ...
Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer
(Springer Singapore, 2022-09-28)
Cell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability ...
Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes
(Springer, 2023-07-15)
Platelets play a significant role in the pathophysiology of ischemic stroke since they are involved in the formation of intravascular thrombus after erosion or rupture of the atherosclerotic plaques. Platelet (PLT) count ...
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)
Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ...
Differential molecular mechanistic behavior of HDACs in cancer progression
(Springer, 2022-08-16)
Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer development. ...
Design, Synthesis, and Anticancer Evaluation of Hemithioindigos via Inhibition of Human Topoisomerases
(John Wiley and Sons Inc, 2023-11-06)
Hemithioindigos were designed as topoisomerase inhibitors, synthesized, and evaluated for their anticancer properties against lung (A549) and breast (MDA-MB-468 and MCF7) cancer cell lines. Among all the synthetics, three ...