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In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation
(Taylor and Francis Ltd., 2018)
Despite the various research efforts toward the treatment of stress-related disorders, the drug has not yet launched last 20?years. Corticotropin releasing factor-1 receptor antagonists have been point of great interest ...
Recent updates on the therapeutic potential of HER2 tyrosine kinase inhibitors for the treatment of breast cancer
(Bentham Science Publishers B.V., 2018)
HER2 positive breast cancer is characterized by the low survival rate in the metastatic patients. Development of resistance and disease-relapse are the major problems associated with the currently available therapies for ...
Research advances in Apert syndrome
(Elsevier B.V., 2018)
Apert syndrome is one of the several genetic syndromes associated with craniosynostosis, a condition that includes premature fusion of one or multiple cranial sutures. There has been significant clinical variation among ...
Apert's syndrome: Study by whole exome sequencing
(Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo, 2018)
In the present study we attempted a parent-child trio, whole exome sequencing (WES) approach to study Apert's syndrome. Clinical characteristics of the child were noted down and WES was carried out using Ion Torrent System ...
PPInS: a repository of protein-protein interaction sitesbase
(Nature Publishing Group, 2018)
Protein-Protein Interaction Sitesbase (PPInS), a high-performance database of protein-protein interacting interfaces, is presented. The atomic level information of the molecular interaction happening amongst various protein ...
Role of p53 gene in breast cancer: Focus on mutation spectrum and therapeutic strategies
(Bentham Science Publishers B.V., 2018)
TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression of various genes that are directly or indirectly under the ...
Synthetic versus enzymatic pictet-spengler reaction: An overview
(Bentham Science Publishers B.V., 2018)
Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having ...
Literature survey of HDACs in cancer and in-vitro analysis of HDAC inhibitor mediated chemo-sensitization
(Central University of Punjab, 2018)
HDACs are chromatin modifying enzymes and post translational modifiers regulating transcription and activity of various proteins such as tubulin, Hsp90 and cortactin respectively. HDAC is divided into four classes (Class ...
Study the effect of phytochemicals phenethyl isothiocyanate (PEITC) and Quercetin on mitochondrial biogenesis in cancer and normal cell lines
(Central University of Punjab, 2018)
Phytochemicals are plant-derived chemicals generally are biologically active compounds and mediate positive health benefits by targeting genes or metabolic pathways of a cell. The phytochemicals examined can be classified ...
Expression of KIBRA in Breast Cancer Cell Lines
(Central University of Punjab, 2018)
Breast cancer the most frequently diagnosed cancer and its metastasis to distant organs accounts the majority of deaths. Numerous genes and proteins are involved in the cause of metastasis. Though KIBRA is one of the ...