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Expression of CHAC1 in Breast Cancer Cell Lines
(Central University of Punjab, 2018)
Breast cancer is the commonly diagnosed type of cancer in women and is a major cause of deaths in women. Unfolded Protein Response Pathway is a signaling pathway induced in endoplasmic reticulum as a stress response. This ...
Analysis of PCNT gene coding sequence in subjects with Microcephalic Osteodysplastic Primordial Dwarfism Type II
(Central University of Punjab, 2018)
Pericentrin (PCNT) is a main scaffold protein of Centrosome. It is encoded by PCNT gene which comprises of 47 exons and its cytogenetic location is 21q22.3. PCNT is a large protein containing 3336 amino acids. In PCNT ...
Analysis of exonic region of PCNT gene in Microcephalic Osteodysplastic Primordial Dwarfism Type II subjects
(Central University of Punjab, 2018)
MOPD II is an autosomal recessive disorder. It is characterised by the presence of
intra uterine growth retardation as well as post natal growth retardation. The adult
height is not more than 100 cm. It has been found ...
Psychological Burden Faced By Vitiligo Patients: A Comparative Study In Kerala And Punjab
(Central University of Punjab, 2018)
Vitiligo is a common chronic skin disease having unknown aetiology, which causes
a disfigurement and variable amount of skin and hair depigmentation and may
affect a patient?s quality of life. To assess the psychological ...
Analysis of pro‐ and anti‐inflammatory cytokine gene variants and serum cytokine levels as prognostic markers in breast cancer
(Wiley, 2018)
The aim of current study was to evaluate the genetic variation in all the genes encoding pro‐ and anti‐inflammatory cytokines in association with breast cancer development in patients from Malwa region of Punjab. The ...
Meta-analysis and estimation of gene expression to establish the role of SFTPD in COPD
(Central University of Punjab, 2018)
COPD is considered to be third leading cause of death by 2020. So far, there is no proper biomarker available for the diagnosis of all the different sub-phenotypes. Multiple GWAS studies have reported the role of SFTPD ...
Association of COX-2 (rs20417) polymorphism with aspirin resistance and adverse drug reactions (if any) in ischemic stroke patients in Malwa region of Punjab.
(Central University of Punjab, 2018)
Ischemic stroke pathology involves the formation of a thrombus over an unstable atherosclerotic plaque through various inflammatory and clotting cascades. Aspirin is the oldest antiplatelet agent with well-established ...
Association of UGT1A6 2 (Ser7Ala) polymorphism with therapeutic response to aspirin in ischemic stroke patients
(Central University of Punjab, 2018)
Ischemic stroke occurs due to the formation of thrombus or embolism within the arteries
due to platelet aggregation. Aspirin therapy is used for the prevention of secondary
stroke. The variant of UGT1A6 (Ser7Ala) gene ...
Investigation for Maternal Uniparental Disomy of Chromosome 7 in a Silver Russell Syndrome patient
(Central University of Punjab, 2018)
Silver-Russell syndrome (SRS) is a genetically heterogeneous disorder. Individuals with SRS show clinical features with varying severity. The major criteria for clinical diagnosis of SRS are intrauterine growth retardation ...
In Silico Design Of Compounds As Sglt2 Inhibitors
(Central University of Punjab, 2018)
SGLT2 inhibitors (SGLT2i) are the current novel therapeutic approach expected to control the growing threat of type 2 diabetes mellitus (T2DM). With comparatively least reported side effects, SGLT2i (gliflozins) have been ...