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Gene-editing, immunological and iPSCs based therapeutics for muscular dystrophy
(Elsevier B.V., 2021-10-15)
Muscular dystrophy is a well-known genetically heterogeneous group of rare muscle disorders. This progressive disease causes the breakdown of skeletal muscles over time and leads to grave weakness. This breakdown is caused ...
FTIR based approach to study EnaC mechanosensory functions
(Elsevier Ltd, 2021-07-19)
The pulmonary epithelial sodium ion channel (ENaC) is gaining importance for its sodium gating and mechanosensitive roles. The mechano functional studies on ENaC suggest direct molecular interactions between the ENaC protein ...
Protocols in apoptosis identification and affirmation
(Elsevier, 2020-10-16)
Protocols are set of predefined written procedural documents that offer guidance or specifications for performing the experiments and its implementation. They are an essential component of good laboratory practice (GLP) ...
Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in rats
(Oxford University Press, 2020-11-26)
Traumatic brain injury (TBI) is an insult to the brain from an external mechanical force, leading to temporary/permanent secondary injuries, i.e. impairment of cognitive, physical, and psycho-social functions with altered ...
Is highly expressed ACE 2 in pregnant women �a curse� in times of COVID-19 pandemic?
(Elsevier Inc., 2020-10-28)
Angiotensin-converting enzyme 2 (ACE 2) is a membrane-bound enzyme that cleaves angiotensin II (Ang II) into angiotensin (1�7). It also serves as an important binding site for SARS-CoV-2, thereby, facilitating viral entry ...
Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review
(Wolters Kluwer Medknow Publications, 2021-08-18)
Since the onset of COVID-19 pandemic, parallel opportunistic infections have also been emerging as another disease spectrum. Among all these opportunistic infection, mucormycosis has become a matter of concern with its ...
Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer�s Disease
(Springer, 2021-11-02)
Alzheimer�s disease (AD) is a neurodegenerative disorder which leads to mental deterioration due to aberrant accretion of misfolded proteins in the brain. According to mitochondrial cascade hypothesis, mitochondrial ...
Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis
(Elsevier Ltd, 2021-11-22)
Polysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of ...
Quercetin Exhibits ?7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents
(Springer, 2021-09-23)
The objective of the present study was to investigate the ?7nAChR-mediated Nrf2-dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial toxicity in Alzheimer�s disease (AD)-like rats. STZ ...
Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer�s disease
(Springer Science and Business Media Deutschland GmbH, 2021-11-23)
Alzheimer�s disease (AD) is a major contributor of dementia leading to the degeneration of neurons in the brain with major symptoms like loss of memory and learning. Many evidences suggest the involvement of neuroinflammation ...