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High-throughput sequencing technologies in metagenomics
(Elsevier, 2022-09-30)
Microbes are a distinct and dynamic group of organisms that require a diverse set of nutritional requirements and environmental conditions to thrive. To culture the desired microorganism a chemically defined media can be ...
Pharmacogenomics of GLP-1 receptor agonists: Focus on pharmacological profile
(Elsevier B.V., 2022-10-28)
Type 2 Diabetes mellitus (T2DM) is a multifactorial metabolic disorder also known as a silent killer disease. Macrovascular and microvascular complications associated with diabetes worsen the condition leading to higher ...
Natural Compound-Based Nanoparticles to Target Free Radicals in Cancer
(Springer Singapore, 2022-09-28)
Cell proliferation and malignant transformation are enabled by genetic and epigenetic changes. During the malignancy process, malignant cells acquire distinguishing characteristics. Cancer cells have acquired the ability ...
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer: An Indian Perspective
(Springer Singapore, 2022-09-28)
Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the importance ...
Assessment of Resting-state functional Magnetic Resonance Imaging Connectivity Among Patients with Major Depressive Disorder: A Comparative Study
(SAGE Publications Inc., 2023-08-29)
Background: Resting-state functional connectivity analysis has a potential to unearth the putative neuronal underpinnings of various disorders of the brain. Major depressive disorder (MDD) is regarded as a disorder arising ...
Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes
(Springer, 2023-07-15)
Platelets play a significant role in the pathophysiology of ischemic stroke since they are involved in the formation of intravascular thrombus after erosion or rupture of the atherosclerotic plaques. Platelet (PLT) count ...
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020-06-17)
Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ...
Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
(Springer-Verlag Italia s.r.l., 2022-09-06)
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most common NDs. A ...
Prognostic significance of CHAC1 expression in breast cancer
(Springer Science and Business Media B.V., 2022-06-21)
Background: An emerging component of Unfolded Protein Response (UPR) pathway, cation transport regulator homolog 1 (CHAC1) has been conferred with the ability to degrade intracellular glutathione and induce apoptosis, ...
Role of Omics in Migraine Research and Management: A Narrative Review
(Springer, 2022-07-07)
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors ...