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Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)
Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ...
Pd-Catalyzed Four-Component Sequential Reaction Delivers a Modular Fluorophore Platform for Cell Imaging
(American Chemical Society, 2019)
A Pd-catalyzed cascade reaction of four versatile privileged synthons is described. The sequential reaction involves the formation of five new chemical bonds by concatenating three distinct chemical steps. One of the ...
Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
(Springer, 2019)
Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is an aggressive BC subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been reported to be ...
Systematic review and meta-analysis to establish the association of common genetic variations in Vitamin D binding protein with chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)
Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport. GC1F, GC1S, and GC2 are the three allelic variants (denoted as rs4588 and rs7041) of GC, ...
Systematic review and meta-analysis confirms significant contribution of surfactant protein D in chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)
Background: Surfactant protein D (SFTPD) is a lung specific protein which performs several key regulatory processes to maintain overall lung function. Several infectious and immune mediated diseases have been shown to be ...
Studies on Genomic Alterations in HER2-Positive Breast Cancer–Focus on Design, Synthesis & Evaluation of Anilinoquinazoline Analogues as Potential HER2 inhibitors
(Central University of Punjab, 2019)
Human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is an aggressive breast cancer subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been ...
KIBRA Team Up with Partners to Promote Breast Cancer Metastasis
(Springer, 2019)
Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized ...
Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
(Frontiers Media S.A., 2019)
Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported ...
Human-lymphocyte cell friendly starch-hydroxyapatite biodegradable composites: Hydrophilic mechanism, mechanical, and structural impact
(John Wiley and Sons Inc., 2019)
Biodegradable starch (Str) polymer was derived from potato, a plant-based natural carbohydrate polymers source, by one-pot synthesis. Hydroxyapatite (HA) was produced from goat bone by step sintering. The inexpensive ...
Computational investigation of binding mechanism of substituted pyrazinones targeting corticotropin releasing factor-1 receptor deliberated for anti-depressant drug design
(Taylor and Francis, 2019)
In spite of various research investigations towards anti-depressant drug discovery program, no one drug has not yet launched last 20 years. Corticotropin-releasing factor-1 (CRF-1) is one of the most validated targets for ...