Department Of Pharmacology

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Browsing Department Of Pharmacology by Author "Arruri, Vijay Kumar"

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    Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
    (MDPI, 2022-08-18T00:00:00) Gundu, Chayanika; Arruri, Vijay Kumar; Yadav, Poonam; Navik, Umashanker; Kumar, Ashutosh; Amalkar, Veda Sudhir; Vikram, Ajit; Gaddam, Ravinder Reddy
    Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a �molecular scissor� to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis. � 2022 by the authors.