(Central University of Punjab, 2018) Choudhary, Diksha; Kumar,Pradeep
Quinoline moiety is an important scaffold in the field of drug discovery and drug development with wide range of pharmacological activities. Its derivatives are potent inhibitors for reverse transcriptase which is responsible for the conversion of single strand viral RNA into double strand viral DNA. In the present study, we have designed and synthesized Pyrazoline containing quinoline derivatives as anti-HIV agents. Six compounds were synthesized and characterized by 1H and 13C NMR and Mass spectrophotometry. The synthesized compounds were also docked on HIV binding site (PDB: 4I2P) and most of these showed good binding interactions with the active domain of the receptor. Our synthesized compounds DC1 and DC6 showed better binding interactions as compared to standard inhibitor Elvitegravir.