(Central University of Punjab, 2018) Dhanka, Ajit Kumar; Kumar, Vinod
Combretastatin A4 (CA4) is a leading agent in vascular disrupting strategies and
tubulin polymerization inhibitor for the tumour therapy. A large number of
combretastatin derivatives have been synthesized as potent inhibitors of Tubulin
which are responsible for the anticancer activity. Combretastatins bind with the
colchicine binding site of the tubulin and disrupt the dynamic equilibrium of tubulin.
IN the current research proposal we have performed 3D-Field based QSAR on
Combretastatins analogue in order to recognize structural features which are
responsible for the tubulin inhibitors activity. The designed compounds are expected
to show good inhibitory activity against tubulin when electrostatic group is attached
in case of compounds 16 and 18, Bulky group is attached in case of compound 26
and hydrophobic group is attached in case of compound 51 respectively.