(Central University of Punjab, 2018) P, Azhar Juman; Rao, Kaki Venkata
Cancer is a disease which starts uncontrolled development of cell as it loses its essential structure and usefulness and that may go ahead to assault and destroy neighboring tissues. Cyclin dependent kinase have major role in control of cell cycle, emphasize their significance as anti-cancer drug targets. Kenpaullone and hymenialdisine are previously reported as potent inhibitors of CDKs with a notable seven membered lactam scaffold. In our research work we synthesized benzazepinone based novel compounds with seven-membered lactam pharmacophore by Fischer indole synthesis and Claisen-Schmidt condensation reactions. Molecular docking study of the synthesized compounds was conducted for understanding the interaction pattern of compounds with CDK2 binding sites which involved in cancer. All synthesized benzazepinone derivatives were having best dock score at the CDK2 binding site and have better G score. Due to the perfect binding interaction of benzazepinone derivatives with CDK2, in future the synthesized molecules will be useful for further testing for evaluating their anticancer activity