Browsing by Author "Ahluwalia, Tarunveer Singh"

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    Editorial: Signal Transduction Inhibitors as Promising Anticancer Agents
    (Hindawi, 2015) Kumar, Raj; Santos, Cedric Dos; Ahluwalia, Tarunveer Singh; Singh, Sandeep
    Cancer is a group of diseases sharing common features like unrestrictive growth, metastasis, and angiogenesis; however the basic signal transduction pathways are deregulated to such an extent that every cancer case itself poses new challenges for the therapeutics. Worldwide approximately 7.6 million people died of cancer in year 2008 and it has been projected that 13.1 million deaths will be due to cancer by year 2030. Understanding the disease etiology and dysregulation of tissue microenvironment, signal transduction pathways are the potential directions, which may help us find the possible cure for the disease. However, recent advances in cancer therapeutics are proving to be beneficial for the patients but there is still a lot to be desired. Continuous research worldwide is focusing on developing better therapeutics as well as finding novel druggable targets for better efficacy. Another recent development is novel multitarget drugs, which may increase the efficacy manyfold.
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    Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
    (BioMed Central Ltd, 2021-11-27T00:00:00) Sharma, Praveen; Sharma, Vibhuti; Ahluwalia, Tarunveer Singh; Dogra, Nilambra; Kumar, Santosh; Singh, Sandeep
    Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional impact within mitochondria is unknown. The main objective of this study is to investigate whether the mitochondrial genome is regulated by miR present inside the mitochondria. Methods and results: Here, we report mitomiR let-7a regulates mitochondrial transcription in breast cancer cells and reprogram the metabolism accordingly. These effects were mediated through the interaction of let-7a with mtDNA, as studied by RNA pull-down assays, altering the activity of Complex I in a cell line-specific manner. Our study, for the first time, identifies the role of mitomiR (let-7a) in regulating the mitochondrial genome by transcriptional repression and its contribution to regulating mitochondrial metabolism of breast cancer cells. Conclusion: These findings uncover a novel mechanism by which mitomiR regulates mitochondrial transcription. � 2021, The Author(s).