Browsing by Author "Anila, Kumari V. S."

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    Medicinal Chemistry Aspects of Isoxazole Analogues as Anti-tubercular Agents
    (Bentham Science Publishers, 2023-10-11T00:00:00) Singh, Harshwardhan; Anila, Kumari V. S.; Singh, Ankit Kumar; Kumar, Adarsh; Kumar, Pradeep
    Tuberculosis (TB) is the major cause of mortality around the world and one of the most common diseases linked to AIDS. Due to the emergence of multi-drug resistance, extensive drug resistance, and total drug resistance strains, TB has become a difficult disease to treat. Isoxazole scaffold shows a wide range of biological activities, including anticancer, antibacterial, anti-tubercular, antiviral, and anti-inflammatory activities etc. Several isoxazole derivatives have been produced and few of them have shown comparable anti-tubercular activity with standard drugs. In this review, we have focused on reported isoxazole derivatives having anti-tubercular activity and summarized their structure-activity relationship. � 2023 Bentham Science Publishers.