Browsing by Author "Banerjee, Bubun"

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    Glycine Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous Ethanol under Refluxed Conditions
    (Bentham Science Publishers, 2022-12-14T00:00:00) Banerjee, Bubun; Kaur, Manmeet; Sharma, Aditi; Singh, Arvind; Priya, Anu; Gupta, Vivek Kumar; Jaitak, Vikas
    Introduction: A facile, convenient and general method has been developed for the one-pot three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles from the reactions of aromatic aldehydes, malononitrile and various C-H activated acids in the presence of a catalytic amount of glycine as an efficient metal-free organocatalyst in aqueous ethanol under refluxed conditions. Methods: Using this developed protocol, we were able to synthesize a series of structurally diverse 2-amino pyran derivatives viz., 2-amino-4,5-dihydropyrano[3,2-c]chromenes, 2-amino-4,5-dihydropyrano [4,3-b]pyrans, 2-amino-5,6,7,8-tetrahydro-4H-chromenes, 2'-amino-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano [3,2-c]chromene]-3'-carbonitrile and 2'-amino-1,3,5'-trioxo-1,3-dihydro-5'H-spiro[indene-2,4'-pyrano[3,2-c]chromene]-3'-carbonitrile in excellent yields. Result: Synthesis of biologically promising pyrans and spiropyrans, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no chromatographic column purifications, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. Conclusion: In conclusion, we have developed a simple, convenient, and efficient method for the synthesis of a series of structurally diverse 2-amino pyran annulated heterocyclic derivatives. � 2022 Bentham Science Publishers.
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    Mandelic acid catalyzed one-pot pseudo three-component synthesis of various trisubstituted methane derivatives at room temperature
    (Arkat, 2022-11-03T00:00:00) Banerjee, Bubun; Singh, Arvind; Sharma, Aditi; Priya, Anu; Kaur, Manmeet; Kaur, Gurpreet; Gupta, Vivek Kumar; Jaitak, Vikas
    A simple, mild, eco-friendly, general and convenient approach has been developed for the synthesis of various trisubstituted methane derivatives via one-pot pseudo three-component reactions between one equivalent of aromatic aldehydes and two equivalents of 6-amino-uracils or dimedone respectively using a catalytic amount of mandelic acid as a low cost, commercially available, efficient organo-catalyst in aqueous ethanol at room temperature. � 2022 Arkat. All rights reserved.
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    Sodium Dodecyl Sulphate Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino-3-cyano Substituted Tetrahydrobenzo[b]pyrans and Spiropyrans in Water at Room Temperature
    (Springer, 2023-01-16T00:00:00) Banerjee, Bubun; Priya, Anu; Kaur, Manmeet; Sharma, Aditi; Singh, Arvind; Gupta, Vivek Kumar; Jaitak, Vikas
    A facile and convenient method has been developed for the one-pot three-component synthesis of 2-amino-3-cyano substituted tetrahydrobenzo[b]pyran derivatives from the reactions of aromatic aldehydes, malononitrile and dimedone or 1,3-cyclohexanedione in the presence of a catalytic amount of sodium dodecyl sulphate as an efficient surfactant type catalyst in water at room temperature. Synthesis of 2-amino-3-cyano substituted spiropyrans was also achieved under the same reaction conditions starting from ninhydrin/isatins, malononitrile and dimedone or 1,3-cyclohexanedione. All the reactions were completed within 2.5�h and the desired products afforded in good to excellent yields. Gram scale production of the desired compound was also achieved. Use of water as green solvent, commercially available low cost surfactant type catalyst, high atom economy, excellent yields, energy efficiency, no column chromatographic purifications, reusability of the solvent media, multiple carbon�carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. Graphical Abstract: [Figure not available: see fulltext.] � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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    Trisodium citrate dihydrate catalyzed one-pot pseudo four-component synthesis of fully functionalized pyridine derivatives
    (Taylor and Francis Ltd., 2022-07-22T00:00:00) Sharma, Aditi; Singh, Arvind; Priya, Anu; Kaur, Manmeet; Gupta, Vivek Kumar; Jaitak, Vikas; Banerjee, Bubun
    A facile and convenient method has been developed for the one-pot pseudo-four component synthesis of fully functionalized pyridine derivatives from the reactions of aromatic aldehydes, malononitrile and thiols in the presence of a catalytic amount of trisodium citrate dihydrate as an efficient metal-free catalyst in aqueous ethanol under refluxed conditions. All the reactions were completed within just 45 minutes and the desired products afforded in excellent yields (90�95%). Gram scale production of the desired compound was also achieved. Synthesis of biologically promising scaffolds, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no column chromatographic purifications, reusability of the solvent media, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. � 2022 Taylor & Francis Group, LLC.