Browsing by Author "Banyal, Naveen"

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    An efficient metal-free and catalyst-free C�S/C�O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides
    (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2023-03-02T00:00:00) Sharma, Shubham; Singh, Dharmender; Kumar, Sunit; Vaishali; Jamra, Rahul; Banyal, Naveen; Deepika; Malakar, Chandi C.; Singh, Virender
    An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant. � 2023 Sharma et al.
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    From 2011 to 2022: The development of pyrazole derivatives through the ?,?-unsaturated carbonyl compounds
    (HeteroCorporation, 2023-11-25T00:00:00) Sharma, Shubham; Singh, Virender; Vaishali; Kumar, Rakesh; Jamra, Rahul; Banyal, Naveen; Jyoti
    The synthesis of pyrazole derivative using ?,?-unsaturated carbonyl compounds has attracted increasing attention of the synthetic organic chemist community. Interestingly, the simplicity of the synthetic method, high reactivity, and ease of incorporating diversity into the desired prototype have contributed a lot toward the exploration of ?,?-unsaturated carbonyl compounds by various research groups. Due to the tremendous pharmacological significance of pyrazole derivatives, their synthesis has been one of the leading research frontiers in recent years. As prime examples, sildenafil, zometapin, Celebrex, and rimonabant have been successfully commercialized in the market to treat various life-challenging diseases. Considering the great profile of ?,?-unsaturated carbonyl compound in the synthesis of biologically active pyrazole derivatives, this review incorporates contemporary literature (2011�2022) on the synthesis of pyrazole and its derivatives using ?,?-unsaturated carbonyl compound as a starting precursor. � 2023 Wiley Periodicals LLC.
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    Transition-Metal-Free Cascade C-N Bond Formation: An Effective Strategy for the Synthesis of ?-Carboline N-Fused Imidazolium Acetates and Estimation of their Light-Emitting Properties
    (Georg Thieme Verlag, 2023-08-08T00:00:00) Singh, Manpreet; Vaishali, Vaishali; Deepika, Deepika; Jyoti, Jyoti; Sharma, Shubham; Banyal, Naveen; Kumar, Prashant; Budhalakoti, Bharti; Malakar, Chandi C.; Singh, Virender
    A simple, efficient, and practical metal-free protocol has been devised to synthesize imidazopyrido[3,4-b]indole-based fluorophores decorated with carbazole/ F-carboline/pyridine scaffolds via three consecutive C.N bond formations in a single operation. A wide range of aromatic amines (2-aminopyridines, 3-aminocarbazole, and anilines) were successfully applied to synthesize the complex imidazolium ions. The significant features of this strategy include high efficiency, mild and environmentally benign reaction conditions, no chromatographic purification, and broad substrate scope with excellent yields of the isolated products. Moreover, excellent photophysical properties (up to 85%) were exhibited by these fluorophores. � 2022 Georg Thieme Verlag. All rights reserved.