Browsing by Author "Basu, M"

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    Engineering of gadolinium-decorated graphene oxide nanosheets for multimodal bioimaging and drug delivery
    (American Chemical Society, 2019) Chawda, N; Basu, M; Majumdar, D; Poddar, R; Mahapatra, S.K; Banerjee, I.
    Engineering of water-dispersible Gd3+ ions-decorated reduced graphene oxide (Gd-rGO) nanosheets (NSs) has been performed. The multifunctional capability of the sample was studied as a novel contrast agent for swept source optical coherence tomography and magnetic resonance imaging, and also as an efficient drug-delivery nanovehicle. The synthesized samples were fabricated in a chemically stable condition, and efforts have been put toward improving its biocompatibility by functionalizing with carbohydrates molecules. Gd incorporation in rGO matrix enhanced the fluorouracil (5-FU) drug loading capacity by 34%. The release of the drug was -92% within 72 h. Gd-rGO nanosheets showed significant contrast in comparison to optically responsive bare GO for swept source optical coherence tomography. The longitudinal relaxivity rate (r1) of 16.85 mM-1 s-1 for Gd-rGO was recorded, which was 4 times larger than that of the commercially used clinical contrast agent Magnevist (4 mM-1 s-1) at a magnetic field strength of 1.5 T. © 2019 American Chemical Society.
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    Synthesis of gadolinium oxide nanocuboids for in vitro bioimaging applications
    (Institute of Physics Publishing, 2019) Chawda, N; Mishra, S; Basu, M; Chander, H; Podder, R; Mahapatra, S.K; Banerjee, I.
    Undoped and Eu-doped gadolinium oxide (GGNCs and EGNCs) nanocuboids functionalized with D-gluconic acid (GA) were synthesised by a simple yet unique scheme using all the benign solvents and temperature. Samples were characterized and presented with properties like good dispersity, biocompatibility, and stability required for standard contrast agent used in magnetic resonance imaging (MRI) and optical coherence tomography (OCT). Biological assays such as 3-(4, 5-dimethyl-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) assay, flow cytometry and confocal microscopy were used to determine its biocompatibility, cellular internalization and optical cellular imaging using A549 and H1299 lung cancer cell lines. EGNCs treated with cell lines emitted red fluorescence which was used to track the internalization of EGNCs within the cells. GGNCs sample showed ?20% enhanced MRI relaxivity as compared to EGNCs; whereas EGNCs revealed better contrast in doctor scans of OCT. Samples could be used as promising candidate for other biomedical applications such as drug delivery when equipped with well functionalised drug molecules.