Browsing by Author "Dar, Mohammad Ovais"

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    1,3-Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules
    (John Wiley and Sons Inc, 2023-10-16T00:00:00) Gupta, Nidhi; Saini, Vipin; Basavarajaiah, S.M.; Dar, Mohammad Ovais; Das, Rina; Dahiya, Randhir Singh
    Heterocyclic compounds form an important part of wide range of biologically active molecules. The heteroatom provides them specificity for various receptors. 1,3-oxazine has been considered as a privileged scaffold in many medicinal chemistry applications. Compounds having 1,3-oxazine moiety exhibit broad range of biological applications such as anticancer, antimicrobial, anti-inflammatory, antiplatelet, antitubercular and alpha-glucosidase inhibition activities. In this review, we consolidate the recent developments in the synthesis and biological activities of 1,3-oxazine containing compounds. Also, the structure activity relationship (SAR) studies of different derivatives exhibiting several biological activities are summarized. Database such as Science direct, Pubmed and Google scholar were searched using keywords �1,3-Oxazine�, �synthesis�, �derivatives�, and �biological activities�. The review would provide a lead for the development of competent candidates with 1,3-oxazine moiety having broad range of applications in the treatment of several human disorders. � 2023 Wiley-VCH GmbH.