Browsing by Author "Devi, Nisha"

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    Morita-Baylis-Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products
    (Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2022-07-26T00:00:00) Devi, Nisha; Singh, Virender
    ?-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity at various positions of ?-carboline to generate unique molecular hybrids of biological importance. The present work is a step towards this and assimilates the results related to the exploration of 3-formyl-9H-?-carbolines for the synthesis of ?-carboline C-3 substituted MBH adducts followed by evaluation of their fluorescent characteristic. The effect of contact time, solvent system, concentration and substituents was also studied during investigation of fluorescence properties of these derivatives. � 2022 Devi and Singh; licensee Beilstein-Institut.
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    Synthesis of pyrazolo[4,3-c]quinolines and the C-C bond cleavage during reductive cyclization
    (Japan Institute of Heterocyclic Chemistry, 2021-02-26T00:00:00) Devi, Nisha; Gupta, Antriksh; Gujjarappa, Raghuram; Malakar, Chandi C.; Singh, Virender
    An efficient synthesis of o-nitrophenyl tethered pyrazole-4-carbaldehydes was achieved via Vilsmeier-Haack formylation of hydrazone derivatives which were subjected to Claisen-Schmidt condensation and Morita-Baylis-Hillman (MBH) reaction with various methyl ketones and activated alkenes respectively to generate the corresponding chalcones and MBH adducts. However, successive Fe-mediated reductive cyclization was followed by an unusual C-C bond cleavage which afforded the pyrazolo[4,3-c]quinolines devoid of diverse substituents at C-4 position. � 2021 The Japan Institute of Heterocyclic Chemistry.