Browsing by Author "Gautam, Swati"

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    Management of Chemotherapy Induced Nausea Vomiting (CINV) in Breast Cancer Patients: An Imperative Factor in Patient Compliance
    (Elsevier Inc., 2023-05-11T00:00:00) Gautam, Swati; Sharma, Krishan Kant; Amanat, Muhammed
    Surgery combined with radiation therapy, with or without systemic chemotherapy, hormone therapy, and antihuman epidermal growth factor receptor 2 targeted therapy, is the standard of care for treating breast cancer. Patients with a range of early- and end-stage breast cancer malignancies may experience chemotherapy-induced nausea and vomiting (CINV), which is a frequent side effect. Different routes and neurotransmitters are in charge of controlling various types of CINV, including acute, delayed, anticipatory, breakthrough, and refractory. Breast cancer patients' quality of life may be impacted by CINV symptoms because they may have physical, dietary, and metabolic abnormalities. From a healthcare standpoint, this is difficult because a decline in quality of life (QoL) may prompt patients to stop receiving chemotherapy in the future, which could affect their overall prognosis. To minimize morbidity and overall healthcare expenses for patients receiving emetogenic chemotherapy, CINV must be minimized. On the consequences of chemotherapy-induced nausea and vomiting on the QoL of breast cancer patients, little study has been undertaken. Despite the widespread use of several grading systems, many antiemetic medications are still required to treat CINV successfully. Oncologists must actively manage CINV since it is a serious problem that necessitates both prevention and therapy. The goal of treating CINV is to prevent the clinical, QOL, and financial concerns that emerge from poorly managed CINV. Healthcare professionals and pharmacists can be prepared to adopt the most effective prevention and treatment strategies with updated antiemetic procedures and novel antiemetic medicines. In the current study, we have reviewed the background of CINV, its pathogenesis, risk factors, current recommendations, and therapeutic strategies, including an antiemetic regimen, with a focus on its manifestations in breast cancer chemotherapy. � 2023 Association for Radiologic & Imaging Nursing
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    Zingiber roseum Roscoe. (Zingiberaceae): Current and future perspective
    (Elsevier B.V., 2023-05-07T00:00:00) Amanat, Muhammed; Gautam, Swati; Chalotra, Rishabh; Lal, Kanhaiya; Gupta, Tanya; Agrawal, Rohini; Mojwar, Somdutt; Singh, Randhir
    Introduction: A perennial, aromatic, tuberose plant Zingiber roseum (Roscoe.) (Zingiberaceae), flourishes in tropical and subtropical climates. In Traditional Chinese Medicine, several pharmacological properties of Zingiber roseum have been reported its antiseptic, antivertigo, and antidiarrheal activities. Therefore, the present article aims to provide insights into the ethnomedicinal, phytochemistry, and pharmacology of Zingiber roseum. Methods: The literature was compelled after systematically searching scientific databases, including Scopus, PubMed, Google Scholar, and Research Gate. The selection criteria for the plant comprised the therapeutic potential of Zingiber roseum and its active components. Moreover, to explore anti-diabetic activity, ligands of interest from Z. roseum were evaluated for their affinity towards PPAR-? and PPAR-?. Results and discussions: Out of 200 articles, 140 were selected for the current study, and from the para-topic literature, it was found that Zingiber roseum has numerous pharmacological properties due to the presence of phytoconstituents like flavonoids, alkaloids, phenolic chemicals, terpenoids, saponins, and phytosterols. Furthermore, in silico studies were carried out using PyRx. It was found that rosmarinic acid (-8.3 kcal/mol) and stigmasterol (-11.12 kcal/mol) exhibited the highest binding affinities for PPAR-? and PPAR-?, respectively, when compared to standard Rosiglitazone. Conclusion: It may be concluded that Z. roseum has several therapeutic activities. Moreover, in silico studies revealed the anti-diabetic action of Z. roseum via modulation of PPAR-? and PPAR-?. � 2023 The Author(s)