Browsing by Author "Gupta, Antriksh"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Synthesis of pyrazolo[4,3-c]quinolines and the C-C bond cleavage during reductive cyclization
    (Japan Institute of Heterocyclic Chemistry, 2021-02-26T00:00:00) Devi, Nisha; Gupta, Antriksh; Gujjarappa, Raghuram; Malakar, Chandi C.; Singh, Virender
    An efficient synthesis of o-nitrophenyl tethered pyrazole-4-carbaldehydes was achieved via Vilsmeier-Haack formylation of hydrazone derivatives which were subjected to Claisen-Schmidt condensation and Morita-Baylis-Hillman (MBH) reaction with various methyl ketones and activated alkenes respectively to generate the corresponding chalcones and MBH adducts. However, successive Fe-mediated reductive cyclization was followed by an unusual C-C bond cleavage which afforded the pyrazolo[4,3-c]quinolines devoid of diverse substituents at C-4 position. � 2021 The Japan Institute of Heterocyclic Chemistry.