Browsing by Author "Kajal, Kumari"

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    Design and implementation of intelligent monitoring system for platform security gate based on wireless communication technology using ML
    (Springer, 2021-10-30T00:00:00) Li, Chunying; Niu, Hongxia; Shabaz, Mohammad; Kajal, Kumari
    The platform safety gate is important safety protection equipment in urban rail transit, which makes the rail area relatively independent from the platform waiting area, ensures the safety of passengers, reduces the noise pollution brought by the subway train to the platform, and provides a comfortable waiting environment for passengers. In order to solve the problems of low intelligent degree and single debugging method of railway station safety door equipment data monitoring, a correction algorithm using machine learning based on image grid is proposed. Firstly, based on virtual instrument technology, a set of acoustic signal acquisition and processing systems for sound field visualization is designed and implemented. Then, based on the analysis of requirements, the hardware configuration and system software design are carried out. Finally, the extraction technology of image feature information is adopted, which can reduce the operation time of image target recognition and make the security door control system have real time. The experimental results show that the calibration algorithm is used to calculate the coordinate values of the actual road by using the third-order fitting method. Compared with the coordinate values of the standard grid, the average error of X is 0.0662%, and the average error of Y is 0.0011%. It can not only improve the accuracy of judgment, but also meet the real-time requirements of video monitoring. The system can realize wireless monitoring on the status of platform safety door equipment using machine learning, improve the efficiency of subway operation and the flexibility of station staff maintenance and protection, and ensure the safety and reliability of the platform safety door system. � 2021, The Society for Reliability Engineering, Quality and Operations Management (SREQOM), India and The Division of Operation and Maintenance, Lulea University of Technology, Sweden.
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    The medicinal perspective of 2,4-thiazolidinediones based ligands as antimicrobial, antitumor and antidiabetic agents: A review
    (John Wiley and Sons Inc, 2022-06-18T00:00:00) Kajal, Kumari; Singh, Gurpreet; Pradhan, Tathagata; Bhurta, Deendyal; Monga, Vikramdeep
    2,4-Thiazolidinedione (2,4-TZD), commonly known as glitazone, is a ubiquitous heterocyclic pharmacophore possessing a plethora of pharmacological activities and offering a vast opportunity for structural modification. The diverse range of biological activities endowed with a novel mode of action, low cost, and easy synthesis has attracted the attention of medicinal chemists. Several researchers have integrated the TZD core with different structural fragments to develop a wide range of lead molecules against various clinical disorders. The most common sites for structural modifications at the 2,4-TZD nucleus are the N-3 and the active methylene at C-5. The review covers the recent development of TZD derivatives such as antimicrobial, anticancer, and antidiabetic agents. Various 2,4-TZD based agents or drugs, which are either under clinical development or in the market, are discussed in the study. Different synthetic methodologies for synthesizing the 2,4-TZD core are also included in the manuscript. The importance of various substitutions at N-3 and C-5 and the mechanisms of action and structure�activity relationships are also discussed. We hope this study will serve as a valuable tool for the scientific community engaged in the structural exploitation of the 2,4-TZD core for developing novel drug m\olecules for life-threatening ailments. � 2022 Deutsche Pharmazeutische Gesellschaft.