Browsing by Author "Kant, Kamal"

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    Copper-Catalyzed C(sp3)? Functionalization and Annulation of 2-Bromoaryl Oximes with Active Methylene Compounds towards Synthesis of Isoquinoline N-Oxides
    (John Wiley and Sons Inc, 2023-06-09T00:00:00) Patel, Chandresh K.; Gujjarappa, Raghuram; Kant, Kamal; Ghanta, Susanta; Singh, Virender; Kabi, Arup K.; Al-Zaqri, Nabil; Malakar, Chandi C.
    The established process proceeds through copper (II)-catalyzed C(sp3)? functionalization of ?-diketones/?-ketoesters with 2-bromobenzaldehyde oximes followed by the intramolecular cyclization of in situ generated acylated intermediates to deliver isoquinoline N-oxides. The copper(II) acetate catalyzed C?H functionalization showed maximum efficacy at 60 �C in methanol/toluene as solvent. The described reaction conditions were applicable over a wide range of substrates with a variety of functional groups to yield isoquinoline N-oxides in yields up to 85%. The developed approach was further elucidated by means of control experiments and DFT calculations. � 2023 Wiley-VCH GmbH.
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    Metal- and Hazardous Reagent-Free Transamidation Process: the NH2OH?HCl Promoted N-Formylation and N-Acylation Reaction under Solvent-Less Conditions
    (Taylor and Francis Ltd., 2023-09-14T00:00:00) Devi, Elangbam Pinky; Kant, Kamal; Kaldhi, Dhananjaya; Ghanta, Susanta; Sengupta, Ragini; Al-Zaqri, Nabil; Singh, Virender; Malakar, Chandi C.
    An efficient transamidation process has been described under solvent-less conditions. The transformation has been accomplished by employing NH2OH?HCl as a reagent and amines as substrates. The developed method is achieved in the absence of metals and hazardous reagents. A series of amines were explored to obtain the N-formylation and N-acylation reactions with excellent yields (81-96%) of products. The DFT analysis was also performed, which provides a clear understanding of the described N-formylation process. The postulated mechanism is well supported by the control experiments. � 2023 Taylor & Francis Group, LLC.