Browsing by Author "Kapoor, Harmanpreet Singh"

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    Genetic Variants of Steroidogenesis and Gonadotropin Pathways and Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-analysis
    (Mary Ann Liebert Inc., 2023-10-25T00:00:00) Sharma, Priya; Singh, Abhilash Kumar; Senapati, Sabyasachi; Kapoor, Harmanpreet Singh; Goyal, Lajya Devi; Kaur, Balpreet; Kamra, Pooja; Khetarpal, Preeti
    Genetic variants are predisposing factors to polycystic ovary syndrome (PCOS), a multifactorial condition that often gets triggered due to various environmental factors. The study investigates the association of the variants of genes that are involved in the steroidogenesis pathway or gonadotropin pathway with the risk of PCOS. Appropriate keywords for predetermined genes were used to search in PubMed, Google Scholar, Science Direct, and Central Cochrane Library up to January 11, 2023. PROSPERO (CRD42022275425). Inclusion criteria: (a) case�control study; (b) genotype or allelic data. Exclusion criteria were: (a) duplicate studies; (b) clinical trials, systematic reviews, meta-analysis or conference abstract, case reports; (c) other than the English language; (d) having insufficient data; e) genetic variants for which meta-analysis has been reported recently and does not have a scope of the update. Various genetic models were applied as per data availability. Overall 12 variants of 7 genes were selected for the analysis. Relevant data were extracted from 47 studies which include 10,584 PCOS subjects and 16,150 healthy controls. Meta-analysis indicates a significant association between TOX3 rs4784165 [ORs = 1.08, 95% CI (1.00�1.16)], HMGA2 rs2272046 [ORs = 2.73, 95% CI (1.97�3.78)], YAP1 rs1894116 [OR = 1.22, 95% CI (1.13�1.33)] and increased risk of PCOS. Whereas FSHR rs2268361 [ORs = 0.84, 95% CI (0.78�0.89)] is associated with decreased PCOS risk. When sensitivity analysis was carried out, the association became significant for CYP19 rs700519 and FSHR rs6165 under an additive model. In addition, C9Orf3 rs3802457 became significantly associated with decreased PCOS risk with the removal of one study. Insignificant association was observed for CYP19A (rs2470152), FSHR (rs2349415, rs6166), C9Orf3 (rs4385527), GnRH1 (rs6185) and risk of PCOS. Our findings suggest association of CYP19A (rs700519), TOX3 (rs4784165), HMGA2 (rs2272046), FSHR (rs6165, rs2268361), C9orf3 (rs3802457), and YAP1 (rs1894116) with risk for PCOS. � Mary Ann Liebert, Inc.
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    Parameteric Estimation for Reliability Function of Phased Mission Systems with Series Network
    (World Scientific, 2022-12-20T00:00:00) Dewan, Isha; Jain, Kanchan; Kapoor, Harmanpreet Singh; Rani, Monika
    In this paper, we consider a phased mission system consisting of k phases (subsystems) wherein the control flows sequentially. The mission is successful if tasks associated with every phase are successful. Density and reliability functions of the lifetime of such a system are worked out when the lifetimes of components of the subsystems follow exponential distribution. It is assumed that components in different subsystems are in series configuration and function independently. The subsystems are assumed to operate independently. A simulation study is conducted to find bias of the estimates of the parameters and the reliability function. The Root Mean Square Error (RMSE) of the estimates is also calculated. � 2023 World Scientific Publishing Company.
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    Trace Element Occurrence in Vegetable and Cereal Crops from Parts of Asia: A Meta-data Analysis of Crop-Wise Differences
    (Springer Science and Business Media Deutschland GmbH, 2023-02-13T00:00:00) Kerketta, Anjali; Kumar, Hemant; Powell, Mike A.; Sahoo, Prafulla Kumar; Kapoor, Harmanpreet Singh; Mittal, Sunil
    In the present study, a systematic review along with a meta-analysis was conducted based on relevant studies from 11 Asian countries (1999�2022, Scopus, PubMed, MEDLINE, ScienceDirect, and Google Scholar) to evaluate the crop-wise differences in the accumulation of trace element (TE) in the edible part of different crops (vegetables: leafy (LV), root (RV), fruit (FV); cereal crops: rice (RIC), wheat (WHE), maize (MAZ)). Based on the median concentration�of the compiled data, the TE accumulation in different vegetable crops was ranked in the decreasing order of Fe > Zn > Mn > Cu > Ni > Cr > Pb > Co > Se > Cd > As, and in cereal crops, this is followed as Fe > Zn > Cu > Ni > Cr > Co > Pb > As > Se > Cd > Hg. A clear difference was found between vegetable categories, with a higher accumulation of most of the elements in LV, especially spinach, coriander, radish leaves, mustard, amaranthus, and pakchoi than other vegetable types. Root vegetables displayed higher bioconcentration factors (BCF) than the other two vegetable types. For cereal crops, higher metal contents were found in WHE followed by RIC and MAZ, but RIC had relatively higher BCF for certain metals (As, Cd, Cu, Cr, Ni) and WHE dominated for the remaining metals. When compared with the prescribed safe limits of the non-essential metals (As, Cd, and Pb), this study revealed that the majority of the vegetable and cereal crop contaminations were from Bangladesh, China, India, Iran, and Pakistan. � 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.