Browsing by Author "Kaur, Mandeep"

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CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis
(Taylor and Francis Ltd., 2020-08-28T00:00:00) Sharma, Priya; Kaur, Mandeep; Khetarpal, Preeti
Background: Previously, many studies investigated the association between CYP19 rs2414096(G > A) and susceptibility to develop PCOS. However, results had been inconsistent. Therefore, our systematic review and meta-analysis aimed to identify the association between CYP19 rs2414096 and PCOS risk. Methods: A systematic literature search was done from database PubMed, Google Scholar, Science Direct, and Cochrane Library up to July 15 2020 and statistical analysis was performed by RevMan5.3. Results: A total of seven studies comprised of 1414 PCOS cases and 1276 controls were included in the current meta-analysis. The pooled analysis showed that overall, there is a significant association between CYP19 rs2414096(G > A) and risk of PCOS (OR = 0.74, 95% CI= 0.62�0.88, p =.0008). In dominant model, GG + AG vs GG and recessive genetic model AA vs AG + GG found a significant association (OR = 1.60,95% CI = 1.10�2.31, p =.01; OR = 0.65,95% CI = 0.45�0.93, p =.02) respectively which indicates that GG phenotype might be risk factor for PCOS development. In stratified subgroup analysis, there was significant association between CYP19 rs2414096 polymorphism and PCOS risk for non-Indian population only while no association was found with Indian population. Conclusion: Present meta-analysis studies indicate that CYP19 rs2414096 is associated with PCOS risk and important in pathogenesis of PCOS for many populations but for Indian population more studies are required as Indian population comprises of various subpopulations genetically isolated since long. � 2020 Informa UK Limited, trading as Taylor & Francis Group.
Geospatial analysis of the distribution of urban green spaces: a study of four Indian cities
(Routledge, 2021-07-27T00:00:00) Kaur, Navjotpreet; Kaur, Mandeep; Padhi, Saumya Sibani; Singh, Kiran Kumari
The urban green spaces are immensely significant to ensure quality of life in a city. However, their spatial distribution is found to be inequitable. The study investigates spatial distribution of green space through remote sensing data at different times in four Indian cities. It further examines the distribution of urban parks with respect to the location of slums. The results demonstrate that green spaces in the study areas changed considerably in the last two decades. The public urban parks are far from slum areas, and their spatial distribution is inequitable. Urban green spaces should be considered a matter of environment justice. � 2021 Informa UK Limited, trading as Taylor & Francis Group.
Increased incidence of spontaneous abortions on exposure to cadmium and lead: a systematic review and meta-analysis
(Taylor and Francis Ltd., 2021-06-25T00:00:00) Kaur, Mandeep; Sharma, Priya; Kaur, Rajinder; Khetarpal, Preeti
Background: Spontaneous abortions are the most severe complication of early pregnancy and are a major reproductive health problem. Although this could be caused due to various cytogenetic, immunological, or endocrinological reasons, role of environmental toxicants cannot be ruled out. In order to explore the role of cadmium and lead in causing spontaneous abortions, current systematic review and meta-analysis had been carried out. Methodology: Literature search was performed using appropriate keywords in PubMed, Science Direct, Cochrane Library, and Google Scholar databases up to December 25 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA). Metananalysis was carried out with the help of RevMan software (version 5.3). Results: Meta-analysis of nine studies on cadmium concentrations in blood of women with at least one spontaneous abortions and controls revealed standardized mean difference (SMD)=3.39, 95% CI (2.17, 4.61), with p <.05. Similarly, meta-analysis of eight studies on lead concentrations revealed standardized mean difference (SMD)=6.24, 95% CI (4.34, 8.14), with p <.05. Conclusion: Populations exposed to heavy metals such as cadmium and lead are at higher risk of pregnancy loss. Therefore, couples experiencing repeated pregnancy losses may be screened for heavy metal load. � 2021 Informa UK Limited, trading as Taylor & Francis Group.
Mapping Of Urban Green Spaces Using Remote Sensing Technique: A Study Of Cities Of Punjab
(Central University of Punjab, 2018) Kaur, Mandeep; Singh, Kiran K.
Urban green spaces are important part of urban areas for good/fresh environment. These spaces are helpful in controlling and reducing the pollution and the temperature. These urban spaces provide a variety of services like biodiversity conservation, noise reduction, mitigation of urban heat island effect, prevention of soil erosion and carbon sequestration. Due to increasing urbanization, the quantity and quality of urban green spaces are degraded. So urban authorities are concerned about the management of green areas in the cities. Mapping of vegetation and green spaces play an important role to conserve the environment and sustainable environment in urban areas for authorities. In the study, the remote sensing is used for the mapping the urban green areas. This study probes the vegetation change detection in the four cities of Punjab over the period of 17 years from 2000 to 2017 based on NDVI (Normalized Difference Vegetation Index) by using remote sensing images of Landsat 7 and Sentinel 2 data.
Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review
(John Wiley and Sons Ltd, 2023-01-30T00:00:00) Kaur, Mandeep; Kaur, Rajinder; Chhabra, Kiran; Khetarpal, Preeti
Background: Recurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples. Objective: To investigate the relationship between variants in the candidate susceptibility genes and epigenetic factors to identify risk factors for idiopathic recurrent pregnancy loss (iRPL). Search Strategy: A systematic literature search was performed using PubMed, Google Scholar, ScienceDirect, and Scopus databases. Insilico analysis was carried out using ShinyGO and STRING software. Selection Criteria: Research papers examining the association between variations in genetic and epigenetic factors and iRPL. Data Collection and Analysis: Data were independently extracted by two authors. Main Results: In total, 83 research papers were finally selected for the present study. Among all the genes involved in the pathogenesis of recurrent pregnancy loss, polymorphisms in IL superfamily genes, VEGF, ESR, and MTHFR were the most investigated. Conclusion: Polymorphisms in angiogenesis, immune tolerance, and thrombophilia pathway genes, which occur independently or synergistically, may lead to various complications during fetal development. Identification of multi-allele risk variants and epigenetic factors in women will be helpful in the identification of high-risk pregnancies. Prospero Registration Number: Prospero CRD42021287315. � 2023 International Federation of Gynecology and Obstetrics.
Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review
(Wolters Kluwer Medknow Publications, 2020-10-13T00:00:00) Gautam, Nisha; Kaur, Mandeep; Kaur, Satbir
Polycomb group proteins (PcG) are multi-subunit structure, consisting of polycomb repressive complex 1 (PRC1), PRC2/3, and pleiohomeotic repressive complex. PRC1 is made up of PHC, BMI-1, CBX, and Ring 1A/B. PRC2 protein complex included embryonic ectoderm development, PCL, SUZ12, SET domain, enhancer of zeste homolog-2 protein (EZH2), and Nurf55. The third subunit PhoRC consists of Pho and DSFMBT subunits. One of the important subunits of PcG group of protein is EZH2 (a histone methyltransferase), which catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery and induces silencing of specific gene transcription. In case of breast cancer and prostate cancer, EZH2 is very well studied. Evidence shows that EZH2 is overexpressed and mutated in a variety of human cancers, rendering EZH2 an attractive target for the design of new chemotherapeutic drugs in cancer. EZH2 also functions both as a transcriptional suppressor and a transcriptional co-activator, depending on H3K27me3 or its absence. In this review, we summarized various studies reported till date, elucidating the structure of PRC2 complex, various mechanisms involved with this, and highlighting the role of EZH2 in breast cancer and prostate cancer progression. An increased understanding of the mechanisms that underlie the pathogenesis of wide spectrum of cancers is therefore needed to develop novel therapeutic approaches for this disease and to improve the quality of life in patients. � 2021 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer-Medknow.