Browsing by Author "Kaur, P"

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    Recent advances in decarboxylative C-C bond formation using direct or in situ generated alkenyl acids
    (Taylor and Francis Inc., 2020) Kaur, P; Kumar, V; Kumar, R.
    In recent years, the reactions of abundantly available, inexpensive, and structurally diverse alkenyl acids (-C=C-COOH) with C-X (X�=�halogen) or C-H coupling partner have emerged as vital strategies for the streamlined synthesis of functionalized alkenes with extrusion of innocuous CO2. Various alkenyl acids such as cinnamic acids can act as stable surrogates for the polymerization prone styrenes/olefins, which otherwise need special attention for their handling and storage. Furthermore, cinnamic acids can be easily prepared through various methodologies including Knoevenagel-Doebner (KD) condensation, Heck coupling reaction, etc. Recently, various one-pot tandem methodologies involving the decarboxylative coupling of KD/Heck sequence with C-H or C-X substrate have come into fore. The present review article edifies about the recent advances, scope and limitations for C-C bond formation via (i) direct decarboxylative functionalization of C-X or C-H substrate with alkenyl acids, (ii) tandem one-pot multicomponent decarboxylative approaches (involving in situ generated alkenyl acids) e.g. coupling of KD/Heck sequences with C-X or C-H substrate. � 2019, � 2019 Taylor & Francis.
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    Recent advances in the C(1)-functionalization of tetrahydroisoquinolines via multicomponent reactions
    (Springer, 2020) Kaur, P; Kumar, R.
    (Figure presented.) 1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013-2019. - 2020, Springer Science+Business Media, LLC, part of Springer Nature.