Browsing by Author "Kaur,Ramandeep"

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    Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions
    (Walter de Gruyter GmbH, 2016) Kaur,Ramandeep; Kumar, Bhupinder; Dwivedi, Ashish Ranjan; Kumar, Vinod
    1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective protocol has been developed for the alkylation of 1,2,4- triazole using mild conditions. The 1-alkyl-1,2,4-triazole derivatives were synthesized under microwave conditions using potassium carbonate as a base and ionic liquid (hexylpyridinium bromide) as a solvent. The products were obtained in excellent yield, and the base-ionic liquid combination was recycled for a number of times. ? 2016 by De Gruyter 2016.