Browsing by Author "Kumar, Kamlesh"

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    Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and i n vitro evaluation
    (Newlands Press Ltd, 2023-02-07T00:00:00) Handa, Mayank; Kumar, Kamlesh; Garabadu, Debapriya; Kushawaha, Pramod Kumar; Shukla, Rahul
    Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & methods: The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer. Results: SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. In vitro studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles. Conclusion: Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation. � 2023 Newlands Press.