Browsing by Author "Kumar, Nachimuthu Senthil"

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Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson�s Disease (PD) Patients of Tamil Nadu Population
(Springer, 2023-10-17T00:00:00) Venkatesan, Dhivya; Iyer, Mahalaxmi; Raj, Neethu; Gopalakrishnan, Abilash Valsala; Narayanasamy, Arul; Kumar, Nachimuthu Senthil; Vellingiri, Balachandar
Parkinson�s disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial impact is stated to be one of the causative reasons for PD. In this study, we investigated the mitochondrial membrane potential (MMP), reactive oxygen species (ROS) and adenosine triphosphate (ATP) levels along with mitochondrial tRNA alterations among three age categories of PD. By determining the genetic and organellar functionality using molecular techniques, the ROS levels were reported to be high with decreased MMP and ATP in the late-onset age group than in other two age categories. Likewise, the tRNA significancy in tRNAThr and tRNAGln was noticed with C4335T and G15927A mutations in late-onset and early-onset PD groups respectively. Therefore, from the findings, ageing has shown a disruption in tRNA metabolism leading to critical functioning of ATP synthesis and MMP, causing oxidative stress in PD patients. These physiological outcomes show that ageing has a keen role in the divergence of mitochondrial function, thereby proving a correlation with ageing and maintenance of mitochondrial homeostasis in PD. � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population
(Springer, 2023-03-27T00:00:00) Vellingiri, Balachandar; Venkatesan, Dhivya; Iyer, Mahalaxmi; Mohan, Gomathi; Krishnan, Padmavathi; Sai Krishna, Krothapalli; Sangeetha, R.; Narayanasamy, Arul; Gopalakrishnan, Abilash Valsala; Kumar, Nachimuthu Senthil; Subramaniam, Mohana Devi
Autism spectrum disorder (ASD) is a neurodevelopmental disability that causes social impairment, debilitated verbal or nonverbal conversation, and restricted/repeated behavior. Recent research reveals that mitochondrial dysfunction and oxidative stress might play a pivotal role in ASD condition. The goal of this case�control study was to investigate oxidative stress and related alterations in ASD patients. In addition, the impact of mitochondrial DNA (mtDNA) mutations, particularly MT-ATP6, and its link with oxidative stress in ASD was studied. We found that ASD patient�s plasma had lower superoxide dismutase (SOD) and higher catalase (CAT) activity, resulting in lower SOD/CAT ratio. MT-ATP6 mutation analysis revealed that four variations, 8865 G>A, 8684 C>T, 8697 G>A, and 8836 A>G, have a frequency of more than 10% with missense and synonymous (silent) mutations. It was observed that abnormalities in mitochondrial complexes (I, III, V) are more common in ASD, and it may have resulted in MT-ATP6 changes or vice versa. In conclusion, our findings authenticate that oxidative stress and genetics both have an equal and potential role behind ASD and we recommend to conduct more such concurrent research to understand their unique mechanism for better diagnosis and therapeutic for ASD. Graphical Abstract: [Figure not available: see fulltext.] � 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
(Elsevier B.V., 2023-06-23T00:00:00) Ong, Kanyin Liane; Stafford, Lauryn K.; McLaughlin, Susan A.; Boyko, Edward J.; Vollset, Stein Emil; Smith, Amanda E.; Dalton, Bronte E.; Duprey, Joe; Cruz, Jessica A.; Hagins, Hailey; Lindstedt, Paulina A.; Aali, Amirali; Abate, Yohannes Habtegiorgis; Abate, Melsew Dagne; Abbasian, Mohammadreza; Abbasi-Kangevari, Zeinab; Abbasi-Kangevari, Mohsen; ElHafeez, Samar Abd; Abd-Rabu, Rami; Abdulah, Deldar Morad; Abdullah, Abu Yousuf Md; Abedi, Vida; Abidi, Hassan; Aboagye, Richard Gyan; Abolhassani, Hassan; Abu-Gharbieh, Eman; Abu-Zaid, Ahmed; Adane, Tigist Demssew; Adane, Denberu Eshetie; Addo, Isaac Yeboah; Adegboye, Oyelola A.; Adekanmbi, Victor; Adepoju, Abiola Victor; Adnani, Qorinah Estiningtyas Sakilah; Afolabi, Rotimi Felix; Agarwal, Gina; Aghdam, Zahra Babaei; Agudelo-Botero, Marcela; Arriagada, Constanza Elizabeth Aguilera; Agyemang-Duah, Williams; Ahinkorah, Bright Opoku; Ahmad, Danish; Ahmad, Rizwan; Ahmad, Sajjad; Ahmad, Aqeel; Ahmadi, Ali; Ahmadi, Keivan; Ahmed, Ayman; Ahmed, Ali; Ahmed, Luai A.; Ahmed, Syed Anees; Ajami, Marjan; Akinyemi, Rufus Olusola; Al Hamad, Hanadi; Al Hasan, Syed Mahfuz; AL-Ahdal, Tareq Mohammed Ali; Alalwan, Tariq A.; Al-Aly, Ziyad; AlBataineh, Mohammad T.; Alcalde-Rabanal, Jacqueline Elizabeth; Alemi, Sharifullah; Ali, Hassam; Alinia, Tahereh; Aljunid, Syed Mohamed; Almustanyir, Sami; Al-Raddadi, Rajaa M.; Alvis-Guzman, Nelson; Amare, Firehiwot; Ameyaw, Edward Kwabena; Amiri, Sohrab; Amusa, Ganiyu Adeniyi; Andrei, Catalina Liliana; Anjana, Ranjit Mohan; Ansar, Adnan; Ansari, Golnoosh; Ansari-Moghaddam, Alireza; Anyasodor, Anayochukwu Edward; Arabloo, Jalal; Aravkin, Aleksandr Y.; Areda, Demelash; Arifin, Hidayat; Arkew, Mesay; Armocida, Benedetta; Arnlov, Johan; Artamonov, Anton A.; Arulappan, Judie; Aruleba, Raphael Taiwo; Arumugam, Ashokan; Aryan, Zahra; Asemu, Mulu Tiruneh; Asghari-Jafarabadi, Mohammad; Askari, Elaheh; Asmelash, Daniel; Astell-Burt, Thomas; Athar, Mohammad; Athari, Seyyed Shamsadin; Atout, Maha Moh'd Wahbi; Avila-Burgos, Leticia; Awaisu, Ahmed; Azadnajafabad, Sina; Darshan, B.B.; Babamohamadi, Hassan; Badar, Muhammad; Badawi, Alaa; Badiye, Ashish D.; Baghcheghi, Nayereh; Bagheri, Nasser; Bagherieh, Sara; Bah, Sulaiman; Bahadory, Saeed; Bai, Ruhai; Baig, Atif Amin; Baltatu, Ovidiu Constantin; Baradaran, Hamid Reza; Barchitta, Martina; Bardhan, Mainak; Barengo, Noel C.; Barnighausen, Till Winfried; Barone, Mark Thomaz Ugliara; Barone-Adesi, Francesco; Barrow, Amadou; Bashiri, Hamideh; Basiru, Afisu; Basu, Sanjay; Basu, Saurav; Batiha, Abdul-Monim Mohammad; Batra, Kavita; Bayih, Mulat Tirfie; Bayileyegn, Nebiyou Simegnew; Behnoush, Amir Hossein; Bekele, Alehegn Bekele; Belete, Melaku Ashagrie; Belgaumi, Uzma Iqbal; Belo, Luis; Bennett, Derrick A.; Bensenor, Isabela M.; Berhe, Kidanemaryam; Berhie, Alemshet Yirga; Bhaskar, Sonu; Bhat, Ajay Nagesh; Bhatti, Jasvinder Singh; Bikbov, Boris; Bilal, Faiq; Bintoro, Bagas Suryo; Bitaraf, Saeid; Bitra, Veera R.; Bjegovic-Mikanovic, Vesna; Bodolica, Virginia; Boloor, Archith; Brauer, Michael; Brazo-Sayavera, Javier; Brenner, Hermann; Butt, Zahid A.; Calina, Daniela; Campos, Luciana Aparecida; Campos-Nonato, Ismael R.; Cao, Yin; Cao, Chao; Car, Josip; Carvalho, Marcia; Castaneda-Orjuela, Carlos A.; Catala-Lopez, Ferran; Cerin, Ester; Chadwick, Joshua; Chandrasekar, Eeshwar K.; Chanie, Gashaw Sisay; Charan, Jaykaran; Chattu, Vijay Kumar; Chauhan, Kirti; Cheema, Huzaifa Ahmad; Abebe, Endeshaw Chekol; Chen, Simiao; Cherbuin, Nicolas; Chichagi, Fatemeh; Chidambaram, Saravana Babu; Cho, William C. S.; Choudhari, Sonali Gajanan; Chowdhury, Rajiv; Chowdhury, Enayet Karim; Chu, Dinh-Toi; Chukwu, Isaac Sunday; Chung, Sheng-Chia; Coberly, Kaleb; Columbus, Alyssa; Contreras, Daniela; Cousin, Ewerton; Criqui, Michael H.; Cruz-Martins, Natalia; Cuschieri, Sarah; Dabo, Bashir; Dadras, Omid; Dai, Xiaochen; Damasceno, Albertino Antonio Moura; Dandona, Rakhi; Dandona, Lalit; Das, Saswati; Dascalu, Ana Maria; Dash, Nihar Ranjan; Dashti, Mohsen; Davila-Cervantes, Claudio Alberto; De la Cruz-Gongora, Vanessa; Debele, Gebiso Roba; Delpasand, Kourosh; Demisse, Fitsum Wolde; Demissie, Getu Debalkie; Deng, Xinlei; Denova-Gutierrez, Edgar; Deo, Salil V.; Dervi�evi?, Emina; Desai, Hardik Dineshbhai; Desale, Aragaw Tesfaw; Dessie, Anteneh Mengist; Desta, Fikreab; Dewan, Syed Masudur Rahman; Dey, Sourav; Dhama, Kuldeep; Dhimal, Meghnath; Diao, Nancy; Diaz, Daniel; Dinu, Monica; Diress, Mengistie; Djalalinia, Shirin; Doan, Linh Phuong; Dongarwar, Deepa; dos Santos Figueiredo, Francisco Winter; Duncan, Bruce B.; Dutta, Siddhartha; Dziedzic, Arkadiusz Marian; Edinur, Hisham Atan; Ekholuenetale, Michael; Ekundayo, Temitope Cyrus; Elgendy, Islam Y.; Elhadi, Muhammed; El-Huneidi, Waseem; Elmeligy, Omar Abdelsadek Abdou; Elmonem, Mohamed A.; Endeshaw, Destaw; Esayas, Hawi Leul; Eshetu, Habitu Birhan; Etaee, Farshid; Fadhil, Ibtihal; Fagbamigbe, Adeniyi Francis; Fahim, Ayesha; Falahi, Shahab; Faris, MoezAlIslam Ezzat Mahmoud; Farrokhpour, Hossein; Farzadfar, Farshad; Fatehizadeh, Ali; Fazli, Ghazal; Feng, Xiaoqi; Ferede, Tomas Y.; Fischer, Florian; Flood, David; Forouhari, Ali; Foroumadi, Roham; Koudehi, Masoumeh Foroutan; Gaidhane, Abhay Motiramji; Gaihre, Santosh; Gaipov, Abduzhappar; Galali, Yaseen; Ganesan, Balasankar; Garcia-Gordillo, M.A.; Gautam, Rupesh K.; Gebrehiwot, Mesfin; Gebrekidan, Kahsu Gebrekirstos; Gebremeskel, Teferi Gebru; Getacher, Lemma; Ghadirian, Fataneh; Ghamari, Seyyed-Hadi; Nour, Mohammad Ghasemi; Ghassemi, Fariba; Golechha, Mahaveer; Goleij, Pouya; Golinelli, Davide; Gopalani, Sameer Vali; Guadie, Habtamu Alganeh; Guan, Shi-Yang; Gudayu, Temesgen Worku; Guimaraes, Rafael Alves; Guled, Rashid Abdi; Gupta, Rajeev; Gupta, Kartik; Gupta, Veer Bala; Gupta, Vivek Kumar; Gyawali, Bishal; Haddadi, Rasool; Hadi, Najah R.; Haile, Teklehaimanot Gereziher; Hajibeygi, Ramtin; Haj-Mirzaian, Arvin; Halwani, Rabih; Hamidi, Samer; Hankey, Graeme J.; Hannan, Md Abdul; Haque, Shafiul; Harandi, Hamid; Harlianto, Netanja I.; Mahmudul Hasan, S.M.; Hasan, Syed Shahzad; Hasani, Hamidreza; Hassanipour, Soheil; Hassen, Mohammed Bheser; Haubold, Johannes; Hayat, Khezar; Heidari, Golnaz; Heidari, Mohammad; Hessami, Kamran; Hiraike, Yuta; Holla, Ramesh; Hossain, Sahadat; Hossain, Md Shakhaoat; Hosseini, Mohammad-Salar; Hosseinzadeh, Mehdi; Hosseinzadeh, Hassan; Huang, Junjie; Huda, Md Nazmul; Hussain, Salman; Huynh, Hong-Han; Hwang, Bing-Fang; Ibitoye, Segun Emmanuel; Ikeda, Nayu; Ilic, Irena M.; Ilic, Milena D.; Inbaraj, Leeberk Raja; Iqbal, Afrin; Islam, Sheikh Mohammed Shariful; Islam, Rakibul M.; Ismail, Nahlah Elkudssiah; Iso, Hiroyasu; Isola, Gaetano; Itumalla, Ramaiah; Iwagami, Masao; Iwu, Chidozie C. D.; Iyamu, Ihoghosa Osamuyi; Iyasu, Assefa N.; Jacob, Louis; Jafarzadeh, Abdollah; Jahrami, Haitham; Jain, Rajesh; Jaja, Chinwe; Jamalpoor, Zahra; Jamshidi, Elham; Janakiraman, Balamurugan; Jayanna, Krishnamurthy; Jayapal, Sathish Kumar; Jayaram, Shubha; Jayawardena, Ranil; Jebai, Rime; Jeong, Wonjeong; Jin, Yinzi; Jokar, Mohammad; Jonas, Jost B.; Joseph, Nitin; Joseph, Abel; Joshua, Charity Ehimwenma; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Kaambwa, Billingsley; Kabir, Ali; Kabthymer, Robel Hussen; Kadashetti, Vidya; Kahe, Farima; Kalhor, Rohollah; Kandel, Himal; Karanth, Shama D.; Karaye, Ibraheem M.; Karkhah, Samad; Katoto, Patrick D. M. C.; Kaur, Navjot; Kazemian, Sina; Kebede, Sewnet Adem; Khader, Yousef Saleh; Khajuria, Himanshu; Khalaji, Amirmohammad; Khan, Moien A. B.; Khan, Maseer; Khan, Ajmal; Khanal, Saval; Khatatbeh, Moawiah Mohammad; Khater, Amir M.; Khateri, Sorour; Khorashadizadeh, Fatemeh; Khubchandani, Jagdish; Kibret, Biruk Getahun; Kim, Min Seo; Kimokoti, Ruth W.; Kisa, Adnan; Kivimaki, Mika; Kolahi, Ali-Asghar; Komaki, Somayeh; Kompani, Farzad; Koohestani, Hamid Reza; Korzh, Oleksii; Kostev, Karel; Kothari, Nikhil; Koyanagi, Ai; Krishan, Kewal; Krishnamoorthy, Yuvaraj; Defo, Barthelemy Kuate; Kuddus, Mohammed; Kuddus, Md Abdul; Kumar, Rakesh; Kumar, Harish; Kundu, Satyajit; Kurniasari, Maria Dyah; Kuttikkattu, Ambily; Vecchia, Carlo La; Lallukka, Tea; Larijani, Bagher; Larsson, Anders O.; Latief, Kamaluddin; Lawal, Basira Kankia; Le, Thao Thi Thu; Le, Trang Thi Bich; Lee, Shaun Wen Huey; Lee, Munjae; Lee, Wei-Chen; Lee, Paul H.; Lee, Sang-Woong; Lee, Seung Won; Legesse, Samson Mideksa; Lenzi, Jacopo; Li, Yongze; Li, Ming-Chieh; Lim, Stephen S.; Lim, Lee-Ling; Liu, Xuefeng; Liu, Chaojie; Lo, Chun-Han; Lopes, Graciliana; Lorkowski, Stefan; Lozano, Rafael; Lucchetti, Giancarlo; Maghazachi, Azzam A.; Mahasha, Phetole Walter; Mahjoub, Soleiman; Mahmoud, Mansour Adam; Mahmoudi, Razzagh; Mahmoudimanesh, Marzieh; Mai, Anh Tuan; Majeed, Azeem; Sanaye, Pantea Majma; Makris, Konstantinos Christos; Malhotra, Kashish; Malik, Ahmad Azam; Malik, Iram; Mallhi, Tauqeer Hussain; Malta, Deborah Carvalho; Mamun, Abdullah A.; Mansouri, Borhan; Marateb, Hamid Reza; Mardi, Parham; Martini, Santi; Martorell, Miquel; Marzo, Roy Rillera; Masoudi, Reza; Masoudi, Sahar; Mathews, Elezebeth; Maugeri, Andrea; Mazzaglia, Giampiero; Mekonnen, Teferi; Meshkat, Mahboobeh; Mestrovic, Tomislav; Jonasson, Junmei Miao; Miazgowski, Tomasz; Michalek, Irmina Maria; Minh, Le Huu Nhat; Mini, G.K.; Miranda, J. Jaime; Mirfakhraie, Reza; Mirrakhimov, Erkin M.; Mirza-Aghazadeh-Attari, Mohammad; Misganaw, Awoke; Misgina, Kebede Haile; Mishra, Manish; Moazen, Babak; Mohamed, Nouh Saad; Mohammadi, Esmaeil; Mohammadi, Mohsen; Mohammadian-Hafshejani, Abdollah; Mohammadshahi, Marita; Mohseni, Alireza; Mojiri-Forushani, Hoda; Mokdad, Ali H.; Momtazmanesh, Sara; Monasta, Lorenzo; Moniruzzaman, Md; Mons, Ute; Montazeri, Fateme; Ghalibaf, AmirAli Moodi; Moradi, Yousef; Moradi, Maryam; Sarabi, Mostafa Moradi; Morovatdar, Negar; Morrison, Shane Douglas; Morze, Jakub; Mossialos, Elias; Mostafavi, Ebrahim; Mueller, Ulrich Otto; Mulita, Francesk; Mulita, Admir; Murillo-Zamora, Efren; Musa, Kamarul Imran; Mwita, Julius C.; Nagaraju, Shankar Prasad; Naghavi, Mohsen; Nainu, Firzan; Nair, Tapas Sadasivan; Najmuldeen, Hastyar Hama Rashid; Nangia, Vinay; Nargus, Shumaila; Naser, Abdallah Y.; Nassereldine, Hasan; Natto, Zuhair S.; Nauman, Javaid; Nayak, Biswa Prakash; Ndejjo, Rawlance; Negash, Hadush; Negoi, Ruxandra Irina; Nguyen, Hau Thi Hien; Nguyen, Dang H.; Nguyen, Phat Tuan; Nguyen, Van Thanh; Nguyen, Hien Quang; Niazi, Robina Khan; Nigatu, Yeshambel T.; Ningrum, Dina Nur Anggraini; Nizam, Muhammad A.; Nnyanzi, Lawrence Achilles; Noreen, Mamoona; Noubiap, Jean Jacques; Nzoputam, Ogochukwu Janet; Nzoputam, Chimezie Igwegbe; Oancea, Bogdan; Odogwu, Nkechi Martina; Odukoya, Oluwakemi Ololade; Ojha, Vivek Anand; Okati-Aliabad, Hassan; Okekunle, Akinkunmi Paul; Okonji, Osaretin Christabel; Okwute, Patrick Godwin; Olufadewa, Isaac Iyinoluwa; Onwujekwe, Obinna E.; Ordak, Michal; Ortiz, Alberto; Osuagwu, Uchechukwu Levi; Oulhaj, Abderrahim; Owolabi, Mayowa O.; Padron-Monedero, Alicia; Padubidri, Jagadish Rao; Palladino, Raffaele; Panagiotakos, Demosthenes; Panda-Jonas, Songhomitra; Pandey, Ashok; Pandey, Anamika; Pandi-Perumal, Seithikurippu R.; Stoian, Anca Mihaela Pantea; Pardhan, Shahina; Parekh, Tarang; Parekh, Utsav; Pasovic, Maja; Patel, Jay; Patel, Jenil R.; Paudel, Uttam; Pepito, Veincent Christian Filipino; Pereira, Marcos; Perico, Norberto; Perna, Simone; Petcu, Ionela-Roxana; Petermann-Rocha, Fanny Emily; Podder, Vivek; Postma, Maarten J.; Pourali, Ghazaleh; Pourtaheri, Naeimeh; Prates, Elton Junio Sady; Qadir, Mirza Muhammad Fahd; Qattea, Ibrahim; Raee, Pourya; Rafique, Ibrar; Rahimi, Mehran; Rahimifard, Mahban; Rahimi-Movaghar, Vafa; Rahman, Md Obaidur; Rahman, Muhammad Aziz; Rahman, Mohammad Hifz Ur; Rahman, Mosiur; Rahman, Md Mosfequr; Rahmani, Mohamed; Rahmani, Shayan; Rahmanian, Vahid; Rahmawaty, Setyaningrum; Rahnavard, Niloufar; Rajbhandari, Bibek; Ram, Pradhum; Ramazanu, Sheena; Rana, Juwel; Rancic, Nemanja; Ranjha, Muhammad Modassar Ali Nawaz; Rao, Chythra R.; Rapaka, Deepthi; Rasali, Drona Prakash; Rashedi, Sina; Rashedi, Vahid; Rashid, Ahmed Mustafa; Rashidi, Mohammad-Mahdi; Ratan, Zubair Ahmed; Rawaf, Salman; Rawal, Lal; Redwan, Elrashdy Moustafa Mohamed; Remuzzi, Giuseppe; Rengasamy, Kannan R. R.; Renzaho, Andre M. N.; Reyes, Luis Felipe; Rezaei, Nima; Rezaei, Nazila; Rezaeian, Mohsen; Rezazadeh, Hossein; Riahi, Seyed Mohammad; Rias, Yohanes Andy; Riaz, Muhammad; Ribeiro, Daniela; Rodrigues, Monica; Rodriguez, Jefferson Antonio Buendia; Roever, Leonardo; Rohloff, Peter; Roshandel, Gholamreza; Roustazadeh, Abazar; Rwegerera, Godfrey M.; Saad, Aly M. A.; Saber-Ayad, Maha Mohamed; Sabour, Siamak; Sabzmakan, Leila; Saddik, Basema; Sadeghi, Erfan; Saeed, Umar; Moghaddam, Sahar Saeedi; Safi, Sare; Safi, Sher Zaman; Saghazadeh, Amene; Sharif-Askari, Narjes Saheb; Sharif-Askari, Fatemeh Saheb; Sahebkar, Amirhossein; Sahoo, Soumya Swaroop; Sahoo, Harihar; Saif-Ur-Rahman, K.M.; Sajid, Mirza Rizwan; Salahi, Sarvenaz; Salahi, Saina; Saleh, Mohamed A.; Salehi, Mohammad Amin; Salomon, Joshua A.; Sanabria, Juan; Sanjeev, Rama Krishna; Sanmarchi, Francesco; Santric-Milicevic, Milena M.; Sarasmita, Made Ary; Sargazi, Saman; Sathian, Brijesh; Sathish, Thirunavukkarasu; Sawhney, Monika; Schlaich, Markus P.; Schmidt, Maria Ines; Schuermans, Art; Seidu, Abdul-Aziz; Kumar, Nachimuthu Senthil; Sepanlou, Sadaf G.; Sethi, Yashendra; Seylani, Allen; Shabany, Maryam; Shafaghat, Tahereh; Shafeghat, Melika; Shafie, Mahan; Shah, Nilay S.; Shahid, Samiah; Shaikh, Masood Ali; Shanawaz, Mohd; Shannawaz, Mohammed; Sharfaei, Sadaf; Shashamo, Bereket Beyene; Shiri, Rahman; Shittu, Aminu; Shivakumar, K.M.; Shivalli, Siddharudha; Shobeiri, Parnian; Shokri, Fereshteh; Shuval, Kerem; Sibhat, Migbar Mekonnen; Silva, Luis Manuel Lopes Rodrigues; Simpson, Colin R.; Singh, Jasvinder A.; Singh, Paramdeep; Singh, Surjit; Siraj, Md Shahjahan; Skryabina, Anna Aleksandrovna; Sohag, Abdullah Al Mamun; Soleimani, Hamidreza; Solikhah, Solikhah; Soltani-Zangbar, Mohammad Sadegh; Somayaji, Ranjani; Sorensen, Reed J. D.; Starodubova, Antonina V.; Sujata, Sujata; Suleman, Muhammad; Sun, Jing; Sundstr�m, Johan; Tabar�s-Seisdedos, Rafael; Tabatabaei, Seyyed Mohammad; Tabatabaeizadeh, Seyed-Amir; Tabish, Mohammad; Taheri, Majid; Taheri, Ensiyeh; Taki, Elahe; Tamuzi, Jacques J. L. Lukenze; Tan, Ker-Kan; Tat, Nathan Y.; Taye, Birhan Tsegaw; Temesgen, Worku Animaw; Temsah, Mohamad-Hani; Tesler, Riki; Thangaraju, Pugazhenthan; Thankappan, Kavumpurathu Raman; Thapa, Rajshree; Tharwat, Samar; Thomas, Nihal; Ticoalu, Jansje Henny Vera; Tiyuri, Amir; Tonelli, Marcello; Tovani-Palone, Marcos Roberto; Trico, Domenico; Trihandini, Indang; Tripathy, Jaya Prasad; Tromans, Samuel Joseph; Tsegay, Guesh Mebrahtom; Tualeka, Abdul Rohim; Tufa, Derara Girma; Tyrovolas, Stefanos; Ullah, Sana; Upadhyay, Era; Vahabi, Seyed Mohammad; Vaithinathan, Asokan Govindaraj; Valizadeh, Rohollah; van Daalen, Kim Robin; Vart, Priya; Varthya, Shoban Babu; Vasankari, Tommi Juhani; Vaziri, Siavash; Verma, Madhur Verma; Verras, Georgios-Ioannis; Vo, Danh Cao; Wagaye, Birhanu; Waheed, Yasir; Wang, Ziyue; Wang, Yanqing; Wang, Cong; Wang, Fang; Wassie, Gizachew Tadesse; Wei, Melissa Y. Wei; Weldemariam, Abrha Hailay; Westerman, Ronny; Wickramasinghe, Nuwan Darshana; Wu, YiFan; Wulandari, Ratna D. W. I.; Xia, Juan; Xiao, Hong; Xu, Suowen; Xu, Xiaoyue; Yada, Dereje Y.; Yang, Lin; Yatsuya, Hiroshi; Yesiltepe, Metin; Yi, Siyan; Yohannis, Hunachew Kibret; Yonemoto, Naohiro; You, Yuyi; Zaman, Sojib Bin; Zamora, Nelson; Zare, Iman; Zarea, Kourosh; Zarrintan, Armin; Zastrozhin, Mikhail Sergeevich; Zeru, Naod Gebrekrstos; Zhang, Zhi-Jiang; Zhong, Chenwen; Zhou, Jingjing; Zieli?ska, Magdalena; Zikarg, Yossef Teshome; Zodpey, Sanjay; Zoladl, Mohammad; Zou, Zhiyong; Zumla, Alimuddin; Zuniga, Yves Miel H.; Magliano, Dianna J.; Murray, Christopher J. L.; Hay, Simon I.; Vos, Theo
Background: Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods: Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. Findings: In 2021, there were 529 million (95% uncertainty interval [UI] 500�564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6�1% (5�8�6�5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9�3% [8�7�9�9]) and, at the regional level, in Oceania (12�3% [11�5�13�0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76�1% (73�1�79�5) in individuals aged 75�79 years. Total diabetes prevalence�especially among older adults�primarily reflects type 2 diabetes, which in 2021 accounted for 96�0% (95�1�96�8) of diabetes cases and 95�4% (94�9�95�9) of diabetes DALYs worldwide. In 2021, 52�2% (25�5�71�8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24�3% (18�5�30�4) worldwide between 1990 and 2021. By 2050, more than 1�31 billion (1�22�1�39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16�8% (16�1�17�6) in north Africa and the Middle East and 11�3% (10�8�11�9) in Latin America and Caribbean. By 2050, 89 (43�6%) of 204 countries and territories will have an age-standardised rate greater than 10%. Interpretation: Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers. Funding: Bill & Melinda Gates Foundation. � 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
miRNA in Parkinson's disease:�From pathogenesis to theranostic approaches
(John Wiley and Sons Inc, 2022-12-11T00:00:00) Elangovan, Ajay; Venkatesan, Dhivya; Selvaraj, Priyanka; Pasha, Md. Younus; Babu, Harysh Winster Suresh; Iyer, Mahalaxmi; Narayanasamy, Arul; Subramaniam, Mohana Devi; Valsala Gopalakrishnan, Abilash; Kumar, Nachimuthu Senthil; Vellingiri, Balachandar
Parkinson's disease (PD) is an age associated neurological disorder which is specified by cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non-motor symptoms. Dopaminergic neurons degradation in substantia nigra region and aggregation of ?Syn are the classic signs of molecular defects noticed in PD pathogenesis. The discovery of microRNAs (miRNA) predicted to have a pivotal part in various processes regarding regularizing the cellular functions. Studies on dysregulation of miRNA in PD pathogenesis has recently gained the concern where our review unravels the role of miRNA expression in PD and its necessity in clinical validation for therapeutic development in PD. Here, we discussed how miRNA associated with ageing process in PD through molecular mechanistic approach of miRNAs on sirtuins, tumor necrosis factor-alpha and interleukin-6, dopamine loss, oxidative stress and autophagic dysregulation. Further we have also conferred the expression of miRNAs affected by SNCA gene expression, neuronal differentiation and its therapeutic potential with PD. In conclusion, we suggest more rigorous studies should be conducted on understanding the mechanisms and functions of miRNA in PD which will eventually lead to discovery of novel and promising therapeutics for PD. � 2022 Wiley Periodicals LLC.