Browsing by Author "Kumar, Pawan"

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The imminent role of microRNAs in salivary adenoid cystic carcinoma
(Neoplasia Press, Inc., 2022-11-04T00:00:00) Kumar, Pawan; Kumawat, Ram Kumar; Uttam, Vivek; Behera, Alisha; Rani, Medha; Singh, Neha; Barwal, Tushar Singh; Sharma, Uttam; Jain, Aklank
Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the correct molecular markers for diagnosis, prognosis, and therapeutic target to tame this disease. Recently, we and others have suggested that non-coding RNAs, specifically microRNAs and long non-coding RNAs, can be ideal biomarkers for cancer(s) diagnosis and progression. Herein, we have shown that various miRNAs, like miR-155, miR?103a?3p, miR-21, and miR-130a increase the oncogenesis process, whereas some miRNAs such as miR-140-5p, miR-150, miR-375, miR-181a, miR-98, miR-125a-5p, miR-582-5p, miR-144-3p, miR-320a, miR-187 and miR-101-3p, miR-143-3p inhibit the salivary adenoid cystic carcinoma progression. Furthermore, we have found that miRNAs also target many vital genes and pathways like mitogen-activated protein kinases-snail family transcriptional repressor 2 (MAPK-Snai2), p38/JNK/ERK, forkhead box C1 protein (FOXC1), mammalian target of rapamycin (mTOR), integrin subunit beta 3 (ITGB3), epidermal growth factor receptor (EGFR)/NF-?B, programmed cell death protein 4 (PDCD4), signal transducer and activator of transcription 3 (STAT3), neuroblastoma RAS (N-RAS), phosphatidylinositol-3-kinase (PI3K)/Akt, MEK/ERK, ubiquitin-like modifier activating enzyme 2 (UBA2), tumor protein D52 (TPD52) which play a crucial role in the regulation of salivary adenoid cystic carcinoma. Therefore, we believe that knowledge from this manuscript will help us find the pathogenesis process in salivary adenoid cystic carcinoma and could also give us better biomarkers of diagnosis and prognosis of the disease. � 2022
miR-590�5p: A double-edged sword in the oncogenesis process
(Elsevier Ltd, 2022-06-12T00:00:00) Barwal, Tushar Singh; Singh, Neha; Sharma, Uttam; Bazala, Sonali; Rani, Medha; Behera, Alisha; Kumawat, Ram Kumar; Kumar, Pawan; Uttam, Vivek; Khandelwal, Akanksha; Barwal, Jyoti; Jain, Manju; Jain, Aklank
Accumulating evidence suggests the critical role of miR-590�5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590�5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590�5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590�5p to resolve this apparent paradox. We have also described the involvement of miR-590�5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590�5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. � 2022
Reconstruction of post-little ice age glacier recession in the Lahaul Himalaya, north-west India
(Taylor and Francis Ltd., 2022-12-13T00:00:00) Deswal, Sanjay; Sharma, Milap Chand; Saini, Rakesh; Chand, Pritam; Prakash, Satya; Kumar, Pawan; Barr, Iestyn David; Latief, Syed Umer; Dalal, Padma; Bahuguna, I.M.
Understanding past glaciation and deglaciation is vital for assessing present-day glacier dynamics and response to climate change. We focus on reconstructing past glacier fluctuations in Lahaul, north-west India, a region located between arid Ladakh and the humid the Pir-Panjal range. We focus specifically on six glaciers in the Miyar and Thirot catchments of varying size, aspect and debris cover. To reconstruct past terminus fluctuations of these glaciers, we used repeat terrestrial photography and historical archives as data sets and mapped the terminus positions and latero-terminal moraines in the field along with glacier terminus mapping from high to medium resolution satellite images (e.g. Corona, Hexagon, Landsat and LISS IV). Results show that since the little ice age, all the studied glaciers have experienced terminus retreat and area loss, with average values of 1.46 and 0.9 km2, respectively. Precipitation data show a statistically significant decreasing trend during the last century with an increasing trend in annual average maximum (T max) and minimum (T min) temperature. This warming trend is more statistically significant for T min. Although total ice loss at the six studied glaciers is considerable (5.48 km2), this varies both spatially (i.e. from glacier to glacier) and temporally. We attribute this variability to topographic controls such as glacier hypsometry and another non-climatic factor, i.e. varying degree of debris cover. � 2022 Swedish Society for Anthropology and Geography.