Browsing by Author "Malik, Sonia"

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    A brief overview of potential treatments for viral diseases using natural plant compounds: The case of sars-cov
    (MDPI AG, 2021-06-24T00:00:00) Abiri, Rambod; Abdul-Hamid, Hazandy; Sytar, Oksana; Abiri, Ramin; de Almeida, Eduardo Bezerra; Sharma, Surender K.; Bulgakov, Victor P.; Arroo, Randolph R. J.; Malik, Sonia
    The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds. Since ancient times, herbal medicines have been extensively applied in the treatment and prevention of various infectious diseases in different traditional systems. The purpose of this review is to highlight the potential antiviral activity of plant compounds as effective and reliable agents against viral infections, especially by viruses from the coronavirus group. Various antiviral mechanisms shown by crude plant extracts and plant-derived bioactive compounds are discussed. The understanding of the action mechanisms of complex plant extract and isolated plant-derived compounds will help pave the way towards the combat of this life-threatening disease. Further, molecular docking studies, in silico analyses of extracted compounds, and future prospects are included. The in vitro production of antiviral chemical compounds from plants using molecular pharming is also considered. Notably, hairy root cultures represent a promising and sustainable way to obtain a range of biologically active compounds that may be applied in the development of novel antiviral agents. � 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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    The Curie temperature: a key playmaker in self-regulated temperature hyperthermia
    (Royal Society of Chemistry, 2023-11-13T00:00:00) Niraula, Gopal; Wu, Chengwei; Yu, Xiaogang; Malik, Sonia; Verma, Dalip Singh; Yang, Rengpeng; Zhao, Boxiong; Ding, Shuaiwen; Zhang, Wei; Sharma, Surender Kumar
    The Curie temperature is an important thermo-characteristic of magnetic materials, which causes a phase transition from ferromagnetic to paramagnetic by changing the spontaneous re-arrangement of their spins (intrinsic magnetic mechanism) due to an increase in temperature. The self-control-temperature (SCT) leads to the conversion of ferro/ferrimagnetic materials to paramagnetic materials, which can extend the temperature-based applications of these materials from industrial nanotechnology to the biomedical field. In this case, magnetic induction hyperthermia (MIH) with self-control-temperature has been proposed as a physical thermo-therapeutic method for killing cancer tumors in a biologically safe environment. Specifically, the thermal source of MIH is magnetic nanoparticles (MNPs), and thus their biocompatibility and Curie temperature are two important properties, where the former is required for their clinical application, while the latter acts as a switch to automatically control the temperature of MIH. In this review, we focus on the Curie temperature of magnetic materials and provide a complete overview beginning with basic magnetism and its inevitable relation with Curie's law, theoretical prediction and experimental measurement of the Curie temperature. Furthermore, we discuss the significance, evolution from different types of alloys to ferrites and impact of the shape, size, and concentration of particles on the Curie temperature considering the proposed SCT-based MIH together with their biocompatibility. Also, we highlight the thermal efficiency of MNPs in destroying tumor cells and the significance of a low Curie temperature. Finally, the challenges, concluding remarks, and future perspectives in promoting self-control-temperature based MIH to clinical application are discussed. � 2023 The Royal Society of Chemistry.