Browsing by Author "Pathare, R.S"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Relay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR.
    (Royal Society of Chemistry, 2018) Sawant, D.M.; Sharma, S; Pathare, R.S; Joshi, G; Kalra, S; Sukanya, S; Maurya, A.K.; Metre, R.K; Agnihotri, V.K.; Khan, S.; Kumar, Raj; Pardasania, R. T.
    Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(II)/Ag(I) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase.