Browsing by Author "Sahu, Prachi"

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Role of Omics in Migraine Research and Management: A Narrative Review
(Springer, 2022-07-07T00:00:00) Chaturvedi, Pragya; Khan, Rahul; Sahu, Prachi; Ludhiadch, Abhilash; Singh, Gagandeep; Munshi, Anjana
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors contributing to its susceptibility. Risk factors for migraine include head or neck injury (Arnold, Cephalalgia 38(1):1�211, 2018). Stress and high temperature are known to trigger migraine, while sleep disorders and anxiety are considered to be the comorbid conditions with migraine. Studies have reported various biomarkers, including genetic variants, proteins, and metabolites implicated in migraine�s pathophysiology. Using the �omics� approach, which deals with genetics, transcriptomics, proteomics, and metabolomics, more specific biomarkers for various migraine can be identified. On account of its multifactorial nature, migraine is an ideal study model focusing on integrated omics approaches, including genomics, transcriptomics, proteomics, and metabolomics. The current review has been compiled with an aim to focus on the genomic alterations especially involved in the regulation of glutamatergic neurotransmission, cortical excitability, ion channels, solute carrier proteins, or receptors; their expression in migraine patients and also specific proteins and metabolites, including some inflammatory biomarkers that might represent the migraine phenotype at the molecular level. The systems biology approach holds the promise to understand the pathophysiology of the disease at length and also to identify the specific therapeutic targets for novel interventions. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer: An Indian Perspective
(Springer Singapore, 2022-09-28T00:00:00) Vasudeva, Kanika; Chaturvedi, Pragya; Khan, Rahul; Sahu, Prachi; Munshi, Anjana
Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the importance of redox balance upon which cancer cells thrive to promote oncogenic phenotype. Therefore, it is highly warranted to develop therapies that can disrupt the fine-tuned intracellular reactive oxygen species (ROS) balance of tumor cells. Even though classical chemotherapy, radiotherapy, and many FDA-approved chemotherapeutic drugs modulate ROS levels, the associated side effects make it worthwhile to explore alternative options. Various compounds of natural origin have high efficacy and minimum side effects and pose a low risk of recurrence. This chapter has been compiled to give a thorough account of medicinal plants of Indian origin that have been implicated in ROS modulation and their potential applications in clinical settings. � Springer Nature Singapore Pte Ltd. 2022.
Translation and Validation of ID.Migraine Questionnaire to North-Indian Vernacular Languages
(Wolters Kluwer Medknow Publications, 2023-09-11T00:00:00) Sahu, Prachi; Chaturvedi, Pragya; Khan, Rahul; Singla, Monika; Munshi, Anjana; Singh, Gagandeep
Background: ID-Migraine is an established screening tool for migraine. Translation and validation in more languages can increase its reach and scope. Aim: To translate and validate ID-Migraine for screening migraine patients in two North-Indian vernacular languages, that is, Hindi and Punjabi. Methods: ID Migraine was translated into Hindi and Punjabi. Subjects with headaches in outpatient clinics were administered the questionnaire according to their preferred language of choice and referenced clinical evaluations, performed by an experienced neurologist, based on current the ICHD-3 diagnostic criteria. Results: One hundred subjects with complaints of headaches and 60 healthy controls were recruited after informed consent. Of the 100 subjects with headaches, 73 (73%) screened positive with a translated version of ID-Migraine, and 60 (60%) were eventually diagnosed with migraine without aura. The sensitivity of the Hindi version of ID-Migraine was 94% (95% confidence intervals, 79% to 99%); specificity, 56% (95% CI, 31% to 78%); positive predictive value, 79% (95% CI, 69% to 86%) and negative predictive value, 83% (95% CI, 55% to 95%). The Punjabi version demonstrated a sensitivity of 86% (95% CI, 68% to 96%); specificity, 43% (95% CI, 23% to 66%); PPV, 68% (95% CI, 58% to 76%); and NPV, 69% (95% CI, 44% to 86%). Conclusion: The translated versions of ID-Migraine demonstrated high sensitivity and fair specificity for screening migraine in Indian subjects who speak and understand Hindi and Punjabi. � 2023 Annals of Indian Academy of Neurology.