Browsing by Author "Sharma, Eva"

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Lifestyle modifications and nutrition in Alzheimer's disease
(Elsevier, 2023-06-16T00:00:00) Bhatti, Gurjit Kaur; Mishra, Jayapriya; Sehrawat, Abhishek; Sharma, Eva; Kanozia, Rubal; Navik, Umashanker; Reddy, P. Hemachandra; Bhatti, Jasvinder Singh
Alzheimer's disease (AD) is a progressive chronic neurodegenerative disorder that is increasingly seen in developed and developing countries that subjugate older people. The exacerbation begins with the disease seen with the symptoms like deterioration of mental ability, memory, and cognitive deficits, which ultimately decline the physical activity also, and the severity of this disease causes the death of the patient. There is no proper medication and cure available to date, which can precisely prevent the condition efficiently. But it is essential to diagnose it before its destructive phase and consult for necessary treatments and procedures taken by the patient and the caregivers. Apart from clinical trials, the first and foremost thing is to focus on lifestyle; a way of living can have a more significant impact on a person's health. One can stay healthy for a longer time or fight against the disease by developing strategies like boosting immunity and staying physically fit enough, or else, one can successfully delay the appearance of disease with strong immunity and a healthier lifestyle. And the other promising fact is taking nutritious food, which is helpful to build a robust internal defense system against the diseased condition and lowering the risk of ailments. This chapter will focus on the pathophysiology of Alzheimer's disease, lifestyle modifications, and nutritional interventions in AD. � 2023 Elsevier Inc. All rights reserved.
Protective role of natural products and bioactive compounds in multiple sclerosis
(Elsevier, 2023-06-16T00:00:00) Bhatti, Gurjit Kaur; Singh, Harsh Vikram; Sharma, Eva; Sehrawat, Abhishek; Mishra, Jayapriya; Navik, Umashanker; Hemachandra Reddy, P.; Bhatti, Jasvinder Singh
Multiple sclerosis (MS), a chronic multifactorial disease characterized by progressive demyelination and neurodegeneration, is rising rapidly in young adults. The pathology of the disease is not yet understood completely. However, neuroinflammation, oxidative stress, and hyperactive autoimmune response appear to play a prominent role in the pathogenesis of the disease. Several genetic, nongenetic, and environmental factors are also found associated with this autoimmune disorder. Although, it is still a matter of debate whether diet and lifestyle have an influence during the course of MS. Recent studies have highlighted several beneficial characteristics of natural bioactive compounds such as anti-inflammatory, antioxidative, immunomodulatory, and other neuroprotective effects, indicating their therapeutic potential to reduce the risk or ameliorate the progression of MS. Basically, these bioactive compounds are the chemicals found in minute amounts naturally in plants with peculiar health benefits. In this chapter, we have briefly described various natural bioactive compounds with neuroprotective effects against MS, including the polyphenols, vitamins supplementation, and natural products such as ginger, ashwagandha, and it seems that these compounds play a notable role in the treatment of MS. Further research is required to extend our understanding in developing more effective therapeutic strategies against the disease with lesser side effects. � 2023 Elsevier Inc. All rights reserved.
Stem cells in the treatment of Alzheimer's disease � Promises and pitfalls
(Elsevier B.V., 2023-04-06T00:00:00) Bhatti, Jasvinder Singh; Khullar, Naina; Mishra, Jayapriya; Kaur, Satinder; Sehrawat, Abhishek; Sharma, Eva; Bhatti, Gurjit Kaur; Selman, Ashley; Reddy, P. Hemachandra
Alzheimer's disease (AD) is the most widespread form of neurodegenerative disorder that causes memory loss and multiple cognitive issues. The underlying mechanisms of AD include the build-up of amyloid-? and phosphorylated tau, synaptic damage, elevated levels of microglia and astrocytes, abnormal microRNAs, mitochondrial dysfunction, hormonal imbalance, and age-related neuronal loss. However, the etiology of AD is complex and involves a multitude of environmental and genetic factors. Currently, available AD medications only alleviate symptoms and do not provide a permanent cure. Therefore, there is a need for therapies that can prevent or reverse cognitive decline, brain tissue loss, and neural instability. Stem cell therapy is a promising treatment for AD because stem cells possess the unique ability to differentiate into any type of cell and maintain their self-renewal. This article provides an overview of the pathophysiology of AD and existing pharmacological treatments. This review article focuses on the role of various types of stem cells in neuroregeneration, the potential challenges, and the future of stem cell-based therapies for AD, including nano delivery and gaps in stem cell technology. � 2023 Elsevier B.V.
Trehalose and its Diverse Biological Potential
(Bentham Science Publishers, 2023-06-07T00:00:00) Sharma, Eva; Shruti, P.S.; Singh, Shagun; Singh, Tashvinder; Kaur, Prabhsimran; Jodha, Bhavana; Srivastava, Yashi; Munshi, Anjana; Singh, Sandeep
Trehalose, a disaccharide molecule of natural origin, is known for its diverse biological ap-plications, like in drug development, research application, natural scaffold, stem cell preservation, food, and various other industries. This review has discussed one such diverse molecule �trehalose aka mycose�, and its diverse biological applications with respect to therapeutics. Due to its inertness and higher stability at variable temperatures, it has been developed as a preservative to store stem cells, and later, it has been found to have anticancer properties. Trehalose has recently been associated with modulating cancer cell metabolism, diverse molecular processes, neuroprotective effect, and so on. This article describes the development of trehalose as a cryoprotectant and protein stabilizer as well as a dietary component and therapeutic agent against various diseases. The article discusses its role in diseases via modulation of autophagy, various anticancer pathways, metabolism, inflammation, aging and oxidative stress, cancer metastasis and apoptosis, thus highlighting its diverse biological potential. � 2023 Bentham Science Publishers.
Trehalose and its Diverse Biological Potential
(Bentham Science Publishers, 2023-06-07T00:00:00) Sharma, Eva; Shruti, P.S.; Singh, Shagun; Singh, Tashvinder; Kaur, Prabhsimran; Jodha, Bhavana; Srivastava, Yashi; Munshi, Anjana; Singh, Sandeep
Trehalose, a disaccharide molecule of natural origin, is known for its diverse biological ap-plications, like in drug development, research application, natural scaffold, stem cell preservation, food, and various other industries. This review has discussed one such diverse molecule �trehalose aka mycose�, and its diverse biological applications with respect to therapeutics. Due to its inertness and higher stability at variable temperatures, it has been developed as a preservative to store stem cells, and later, it has been found to have anticancer properties. Trehalose has recently been associated with modulating cancer cell metabolism, diverse molecular processes, neuroprotective effect, and so on. This article describes the development of trehalose as a cryoprotectant and protein stabilizer as well as a dietary component and therapeutic agent against various diseases. The article discusses its role in diseases via modulation of autophagy, various anticancer pathways, metabolism, inflammation, aging and oxidative stress, cancer metastasis and apoptosis, thus highlighting its diverse biological potential. � 2023 Bentham Science Publishers.