Browsing by Author "Singh, Amit Kumar"

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Antitubercular drugs: possible role of natural products acting as antituberculosis medication in overcoming drug resistance and drug-induced hepatotoxicity
(Springer Science and Business Media Deutschland GmbH, 2023-09-04T00:00:00) Rana, Harvesh Kumar; Singh, Amit Kumar; Kumar, Ramesh; Pandey, Abhay K.
Mycobacterium tuberculosis (Mtb) is a pathogenic bacterium which causes tuberculosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatment outcomes. The World Health Organization (WHO) has emphasised the development of not just new individual anti-TB drugs, but also novel medication regimens as an alternative treatment option for the drug-resistant Mtb strains. Many plants, as well as marine creatures (sponge; Haliclona sp.) and fungi, have been continuously used to treat TB in various traditional treatment systems around the world, providing an almost limitless supply of active components. Natural products, in addition to their anti-mycobacterial action, can be used as adjuvant therapy to increase the efficacy of conventional anti-mycobacterial medications, reduce their side effects, and reverse MDR Mtb strain due to Mycobacterium�s genetic flexibility and environmental adaptation. Several natural compounds such as quercetin, ursolic acid, berberine, thymoquinone, curcumin, phloretin, and propolis have shown potential anti-mycobacterial efficacy and are still being explored in preclinical and clinical investigations for confirmation of their efficacy and safety as anti-TB medication. However, more high-level randomized clinical trials are desperately required. The current review provides an overview of drug-resistant TB along with the latest anti-TB medications, drug-induced hepatotoxicity and oxidative stress. Further, the role and mechanisms of action of first and second-line anti-TB drugs and new drugs have been highlighted. Finally, the role of natural compounds as anti-TB medication and hepatoprotectants�have been described and their mechanisms discussed. � 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise
(Baishideng Publishing Group Inc, 2023-01-15T00:00:00) Singh, Amit Kumar; Singh, Shiv Vardan; Kumar, Ramesh; Kumar, Shashank; Senapati, Sabyasachi; Pandey, Abhay K
Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year, with an estimated 5-year survival rate of 30%�35% after diagnosis. Hepatocellular carcinoma (HCC) constitutes a significant subtype of liver cancer (approximate75%) and is considered primary liver cancer. Treatment for liver cancer mainly depends on the stage of its progression, where surgery including, hepatectomy and liver transplantation, and ablation and radiotherapy are the prime choice. For advanced liver cancer, various drugs and immunotherapy are used as first-line treatment, whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic origins. Sorafenib and lenvatinib are first-line therapies, while regorafenib and ramucirumab are secondline therapy. Various metabolic and signaling pathways such as Notch, JAK/ STAT, Hippo, TGF-?, and Wnt have played a critical role during HCC progression. Dysbiosis has also been implicated in liver cancer. Drug-induced toxicity is a key obstacle in the treatment of liver cancer, necessitating the development of effective and safe medications, with natural compounds such as resveratrol, curcumin, diallyl sulfide, and others emerging as promising anticancer agents. This review highlights the current status of liver cancer research, signaling pathways, therapeutic targets, current treatment strategies and the chemopreventive role of various natural products in managing liver cancer � The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved
Temporal Variation of Water Quality Parameters during COVID-19: A Case Study of River Yamuna
(2023-07-20T00:00:00) Singh, Bhupendra Pratap; Pandey, Puneeta; Koul, Monika; Bhatia, Bela; Singh, Amit Kumar; Mehra, Kriti; Chowdhary, Khyati; Kumar, Ranjeet; Goel, Vanshika
Abstract: The novel coronavirus (COVID-19) originated in Wuhan city of China in late December 2019 and affected the (atmosphere and hydrosphere) and also impacted economic activities due to the lockdown. Several studies have reported the impact of the COVID-19 pandemic on significant changes in the air quality index, but only a few studies have reported the relationship between water quality parameters and COVID-19. The findings of the current study revealed that the mean values of pH in the Yamuna river were reported to be 7.77 � 0.31, 7.55 � 0.40, and 7.31 � 0.44 for pre-, during, and post-pandemic periods. The changes in the pH values indicated that Yamuna water quality became less alkaline due to restricted industrial activities along the river during the lockdown period. Further, the mean values of COD were observed to be 60.57 � 16.79, 62.99 � 23.17, and 129.06 � 36.96; the BOD values were 18.20 � 8.42, 20.16 � 5.22, and 33.35 � 10.35, and DO values were 3.30 � 1.15, 3.20 � 0.96, and 3.49 � 1.56 respectively for pre-, during, and post-pandemic periods. The results of these parameters indicated that agriculture, including local source discharges, was a major factor affecting water quality parameters during the pandemic period. According to the study, there is a significant positive association between the BOD and COD with values 0.99, 0.98, and 0.94, respectively, whereas a strong negative correlation was calculated between DO, COD, BOD for pre-, during, and post-pandemic periods. This study would be enlightening among the scientists, researchers, and government to address the water issues along with policy formulation. � 2023, Pleiades Publishing, Ltd.