Browsing by Author "Singh, Gurmeet"

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    A dual stimuli responsive natural polymer based superabsorbent hydrogel engineered through a novel cross-linker
    (Royal Society of Chemistry, 2021-03-23T00:00:00) Mehra, Saloni; Nisar, Safiya; Chauhan, Sonal; Singh, Gurmeet; Singh, Virender; Rattan, Sunita
    Natural protein-based polymers may serve as a potential source for developing advanced porous organic macromolecules, possessing exquisite control over the pores, which impart exceptional properties to these materials. Here, we describe a strategy to design, synthesize and develop an intelligent, dual stimuli responsive highly porous grafted polymer with exquisite control over the functionality of pores. The monomer 2-(4-((acrylamido)methyl)-1H-1,2,3-triazol-1-yl)-4-vinylbenzoic acid as a cross-linker, having pH responsive (acidic functional groups) and thermo-responsive (triazole and acrylamide groups) functional groups, was successfully prepared via click chemistry, for grafting onto the backbone of the natural polymer soy protein isolate (SPI) via microwave irradiation. Alkene groups were introduced at both the sides of the monomer, prior to grafting with SPI. Furthermore, to increase the hydrogen bonding network in the polymer, the pH responsive crosslinker 4-(4-hydroxyphenyl)butanoic acid (HPBA) was introduced while grafting. The grafted soy protein isolate polymer, SPI-g-[2-(4-((acrylamido)methyl)-1H-1,2,3-triazol-1-yl)-4-vinylbenzoicacid-co-4-(4-hydroxyphenyl) butanoic acid]-g-SPI, [SPI-g-(ATVBA-co-HPBA)-g-SPI], is characterized by using TGA for thermal stability, SEM and TEM for visual confirmation, NMR, LCMS and FTIR for grafting confirmation, XRD for crystallinity, MTT assay for cytotoxicity, and BET for analyzing the porous network structure. The size and morphological changes of [SPI-g-(ATVBA-co-HPBA)-g-SPI] are studied under different parameters for its potential use as an advanced porous macromolecule based superabsorbent polymer (SAP). � 2021 The Royal Society of Chemistry.
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    Plasmodium's journey through the Anopheles mosquito: A comprehensive review
    (Elsevier B.V., 2020-12-17T00:00:00) Singh, Meghna; Suryanshu; Kanika; Singh, Gurmeet; Dubey, Alok; Chaitanya, R.K.
    The malaria parasite has an extraordinary ability to evade the immune system due to which the development of a malaria vaccine is a challenging task. Extensive research on malarial infection in the human host particularly during the liver stage has resulted in the discovery of potential candidate vaccines including RTS,S/AS01 and R21. However, complete elimination of malaria would require a holistic multi-component approach. In line with this, under the World Health Organization's PATH Malaria Vaccine Initiative (MVI), the research focus has shifted towards the sexual stages of malaria in the mosquito host. Last two decades of scientific research obtained seminal information regarding the sexual/mosquito stages of the malaria. This updated and comprehensive review would provide the basis for consolidated understanding of cellular, biochemical, molecular and immunological aspects of parasite transmission right from the sexual stage commitment in the human host to the sporozoite delivery back into subsequent vertebrate host by the female Anopheles mosquito. � 2020 Elsevier B.V. and Soci�t� Fran�aise de Biochimie et Biologie Mol�culaire (SFBBM)