Browsing by Author "Singh, P."
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Item Flavonoids: Synthesis and biological activities(Nova Science Publisher Inc., 2018) Kushwaha, P.P.; Singh, P.; Kumar, S.Flavonoid, the biggest class of secondary metabolite, are are found in vegetable, parsley, fruits, and wine. They are divided into distinct subgroups such as flavanols or catechins, flavones, flavanonols, flavanones, and anthocyanins. Flavonoids performs various protective functions against several herbivore, insectivores, and microbes. Some of the flavonoids such ascampothecin and vincristine are approved as anticancer drug. In the present chapter, we focused on different group of flavonoids and their potential functional relationship with the environment and disease. ? 2018 Nova Science Publishers, Inc.Item H2 O2 sensing through electrochemically deposited thionine coated ITO thin film(CMB Association Publications, 2017) Singh, P.; Srivastava, S.; Singh, S. K.Progression and initiation of different diseases including pulmonary diseases, alzheimer’s and tumors are linked with the oxidative stress, an important cause of cell damage. Different antioxidant enzymes are involved in detoxifying reactive oxygen species including hydrogen peroxide (H2O2) that is generated in response to various stimuli and has important role in cell activation & bio-signaling processes. Herein, we developed hydrogen peroxide electrochemical sensor based on horseradish peroxidase (HRP) entrapped polymerized thionine (PTH) film. Electrochemical deposition of thionine (dye) on indium tin oxide (ITO) surface was carried out through chornoamperometry followed by cyclic voltammetry. Deposited thionine thin film obtained was checked for its stability at different scan rates. The PTH-modified electrodes showed linear dependence of peak current with scan rate within the range of 20 to 100 mV s−1. Thionine used as electron transfer mediator between heme site of HRP and electrode. Cyclic voltammetry showed increase in the reduction peak current due to electrocatalytic reduction of H2O2. The sensor detection limit range from 10-1 _ 102 μM and limit of detection was 0.1μM. The proposed sensor has good storage response, cost effective, high sensitivity and wide linear range that could be used for the fabrication of other enzyme based biosensors.Item Health promoting activity of myricetin: A natural flavonoid(Nova Science Publishers, Inc., 2017) Singh, P.; Bast, Felix; Kumar, S.; Kundu, P.Myricetin is a plant-derived flavonoid and is well known for its nutraceuticals value. It is a natural flavonol with hydroxyl groups at 3, 5, 7, 3', 4' and 5' positions, which found in fruits, vegetables, tea, berries and red wine. Furthermore, it can perform the functions including antiinflammation, anti-oxidative stress, anti-inflammatory, anti-apoptotic, neuroprotective properties, and anti-hyperlipidemia. All of those functions may contribute the prevention of cancer, diabetes, and neurodegenerative disease. In the present book chapter, a comprehensive discussion has been made to address the potential benefits of myricetin on cancer, diabetes, and neurodegenerative disease. We also discuss the underlined mechanism involved in the biological action of myricetin. ? 2017 Nova Science Publishers, Inc.Item Impact of rice-husk ash on the soil biophysical and agronomic parameters of wheat crop under a dry tropical ecosystem(Elsevier B.V., 2018) Singh, R.; Srivastava, P.; Singh, P.; Sharma, A.K.; Singh, H.; Raghubanshi, A.S.Several alternative amendments like organic manure and biochar have been proposed for revitalizing the degrading soil viability and fertility for sustainable agriculture, globally. However, detailed field-scale studies focussing on the soil and agronomic parameters of crops under these amendments are limited in dry tropical ecosystems. Therefore, we studied the impact of various soil amendments viz., rice-husk ash (RHA) and farm-yard manure (FYM) along with mineral fertilizer on soil biophysical and agronomic parameters of wheat crop. We specifically explored the impact of the amendments on soil CO2 efflux (SCE, under different growth stages) and the harvest index of wheat crop, which are considered as the key indicators of soil viability and agronomic efficiency, respectively. SCE, soil moisture, soil temperature, soil N, microbial biomass and soil pH were found significantly varying under different treatments (P < 0.05). SCE was found maximum under sole FYM applied and minimum under mineral fertilizer applied treatments, whereas RHA application lowered the SCE as compared to sole FYM application. Moreover, SCE showed variation with plant growth stages, and found maximum during stem elongation followed by heading stage whereas minimum during ripening stage. Soil moisture was found to have considerable regulation for the overall variation in SCE (r2 = 0.17; P = 0.04). In contrast to the soil properties, agronomic parameters (except harvest index) were found higher under mineral fertilizer applied treatments followed by sole FYM and combined FYM + RHA treatments, whereas sole RHA applied treatment showed minimum values. However, significant variations were observed only for harvest index, aboveground dry matter, grain and straw yields (P < 0.05). Further, harvest index was found highest under sole and combined FYM and RHA applied treatments whereas lowest in mineral fertilizer applied treatments. Soil C/N ratio (r2 = 0.16; P = 0.04) and panicle length (r2 = 0.18; P = 0.03), respectively as soil and agronomic parameters, have been found to have considerable control over harvest index. The findings revealed that soil viability is higher under sole FYM and combined FYM + RHA treatments whereas mineral fertilization enhances agronomic performance. Based on the studied two indicators, we conclude that both soil and agronomic sustainability can be maintained by using a combination of organic (FYM and RHA) fertilization with reduced inputs from mineral fertilizers. However, it further needs exploration for various soil and plant eco-physiological parameters of different crops at field level for wider adaptation in the dry tropical region. ? 2018 Elsevier LtdItem Nanomaterial-Blood interactions: Biomedical perspective(The Royal Society of Chemistry, 2018) Singh, P.; Singh, S. K.